Sangwon Yun, PhD
MD/PhD student, MedicineDownloadHi-Res Photo
About
Titles
MD/PhD student, Medicine
Biography
Sangwon grew up in the San Francisco Bay Area and attended Duke University, where he majored in biology with a minor in chemistry. He joined in the MD/PhD program at the Yale School of Medicine in 2017 and completed his dissertation in Genetics studying oncogenic tolerance and chromatin organization in 2023. His clinical interests are in surgical oncology and colorectal surgery, particularly the drivers of early-onset colorectal cancer.
Education & Training
- PhD
- Yale School of Medicine, Genetics (2023)
- BS
- Duke University, Biology (2017)
Research
Publications
2023
Injury prevents Ras mutant cell expansion in mosaic skin
Gallini S, Annusver K, Rahman N, Gonzalez D, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi K, Kasper M, Greco V. Injury prevents Ras mutant cell expansion in mosaic skin. Nature 2023, 619: 167-175. PMID: 37344586, PMCID: PMC10322723, DOI: 10.1038/s41586-023-06198-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsWild-type cellsRas family proteinsCell cycle inhibitor p21Family proteinsOncogenic RasGenetic approachesMosaic tissuesInhibition of EGFRInhibitor p21EGFR ligandsEGFR pathwayCell expansionAberrant growthConstitutive lossDifferential activationParacrine secretionAbsence of injuryCellsCompetitive balanceInjury repairHealthy skinInjurySkinProteinPathwayLive imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo
May D, Yun S, Gonzalez D, Park S, Chen Y, Lathrop E, Cai B, Xin T, Zhao H, Wang S, Gonzalez L, Cockburn K, Greco V. Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo. ELife 2023, 12: e83444. PMID: 36880644, PMCID: PMC10027315, DOI: 10.7554/elife.83444.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsStem cell differentiationCell differentiationStem cell compartmentCompaction changesChromatin compaction statesDynamic transcriptional statesCell compartmentChromatin architectureCell cycle statusChromatin rearrangementNascent RNATranscriptional burstingTranscriptional statesLive imagingTissue contextGene expressionDifferentiating cellsGlobal remodelingIndividual cellsCycle statusStem cellsDifferentiation statusDifferentiationCellsMorphological changes
2022
Double knockin mice show NF-κB trajectories in immune signaling and aging.
Rahman SMT, Aqdas M, Martin EW, Tomassoni Ardori F, Songkiatisak P, Oh KS, Uderhardt S, Yun S, Claybourne QC, McDevitt RA, Greco V, Germain RN, Tessarollo L, Sung MH. Double knockin mice show NF-κB trajectories in immune signaling and aging. Cell Rep 2022, 41: 111682. PMID: 36417863, DOI: 10.1016/j.celrep.2022.111682.Peer-Reviewed Original ResearchFrom start to finish—a molecular link in wound repair
Yun S, Greco V. From start to finish—a molecular link in wound repair. Science 2022, 375: 619-620. PMID: 35143296, DOI: 10.1126/science.abn7411.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2018
Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer.
Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A 2018, 115: E4473-E4482. PMID: 29686080, DOI: 10.1073/pnas.1802354115.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor Full member
International AwardSigma XiDetails07/19/2024honor MacMillan Center International Conference Travel Grant
Yale University AwardDetails03/17/2022honor Society of Investigative Dermatology Travel Award
International AwardDetails03/09/2022
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