2023
Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults
Odriozola P, Kribakaran S, Cohodes E, Zacharek S, McCauley S, Haberman J, Quintela L, Hernandez C, Spencer H, Pruessner L, Caballero C, Gee D. Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults. Biological Psychiatry Global Open Science 2023, 4: 155-164. PMID: 38298801, PMCID: PMC10829678, DOI: 10.1016/j.bpsgos.2023.05.007.Peer-Reviewed Original ResearchSafety signal learningDorsal anterior cingulate cortexTrait anxietyFear reductionEffects of noveltyHippocampal activationSignal learningThreat responsesNeural mechanismsAnxiety disordersFunctional connectivityVentrolateral prefrontal cortex activationInhibition of fearLow trait anxietyCross-species evidenceInferior frontal gyrusHigh trait anxietyPrefrontal cortex activationAnterior cingulate cortexHealthy adultsNeural correlatesFrontal gyrusAnterior hippocampusCortex activationHippocampal involvement
2021
Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiology