2002
Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer
Wheeler MA, Hausladen DA, Yoon JH, Weiss RM. Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer. Journal Of Urology 2002, 168: 1568-1573. PMID: 12352459, DOI: 10.1016/s0022-5347(05)64522-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBCG VaccineCyclooxygenase 1Cyclooxygenase 2DinoprostoneEnzyme InductionFemaleGene Expression Regulation, EnzymologicHumansIsoenzymesMaleMembrane ProteinsMiddle AgedProstaglandin-Endoperoxide SynthasesRNA, MessengerUreterUrinary BladderUrinary Bladder NeoplasmsUrinary Tract InfectionsUrogenital NeoplasmsUrotheliumConceptsUrinary prostaglandin E2 levelsUrinary tract infectionProstaglandin E2 levelsUrinary prostaglandin E2Tract infectionsBladder cancerProstaglandin E2 productionBCG treatmentCOX-2 mRNAUrogenital cancersE2 levelsUrine particulatesBladder muscleInflammatory processProstaglandin E2E2 productionBacillus Calmette-Guerin treatmentCOX-2 protein levelsCOX-2 protein expressionHuman urinary tract infectionsUrinary prostaglandin levelsCOX-2 expressionHuman bladder muscleBladder cancer casesCyclooxygenase-2 inductionProstaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer
WHEELER M, HAUSLADEN D, YOON J, WEISS R. Prostaglandin E2 Production and Cyclooxygenase-2 Induction in Human Urinary Tract Infections and Bladder Cancer. Journal Of Urology 2002, 168: 1568-1573. DOI: 10.1097/00005392-200210010-00086.Peer-Reviewed Original ResearchUrinary prostaglandin E2 levelsUrinary tract infectionProstaglandin E2 levelsUrinary prostaglandin E2Tract infectionsBladder cancerProstaglandin E2 productionBCG treatmentCOX-2 mRNAUrogenital cancersE2 levelsUrine particulatesBladder muscleInflammatory processProstaglandin E2E2 productionBacillus Calmette-Guerin treatmentCOX-2 protein levelsCOX-2 protein expressionHuman urinary tract infectionsUrinary prostaglandin levelsCOX-2 expressionHuman bladder muscleBladder cancer casesCyclooxygenase-2 induction
2000
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients
Smith S, Wheeler M, Lorber M, Weiss R. Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients. Kidney International 2000, 58: 829-837. PMID: 10916108, DOI: 10.1046/j.1523-1755.2000.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultCreatinineCyclic GMPCytokinesFemaleFollow-Up StudiesGraft RejectionHumansInterleukin-10Interleukin-2Interleukin-6Interleukin-8Kidney Failure, ChronicKidney TransplantationMaleMiddle AgedNitratesNitric OxideNitritesPredictive Value of TestsTime FactorsTumor Necrosis Factor-alphaUrinary Tract InfectionsConceptsUrinary tract infectionRenal transplant patientsAcute rejectionTransplant patientsCyclic GMPIL-2Nitric oxideNitric oxide synthase activityAdditional urine specimensUrine cytokine levelsUrine nitrate levelsNitric oxide productsMonths of transplantationOxide synthase activityUrine nitrateSoluble interleukinCytokine levelsTract infectionsIL-10IL-6IL-8Tumor necrosisUrine specimensPatientsClinical diagnosis
1999
Induction of Nitric Oxide Synthase with Urinary Tract Infections
Wheeler M, Smith S, Weiss R. Induction of Nitric Oxide Synthase with Urinary Tract Infections. Advances In Experimental Medicine And Biology 1999, 462: 359-369. PMID: 10599439, DOI: 10.1007/978-1-4615-4737-2_28.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseOxide synthaseNitric oxideEnzyme nitric oxide synthaseUrinary tract infectionCyclic GMPNon-cholinergic neuronsGuanylyl cyclase enzymeTract infectionsL-arginineL-citrullineCyclase enzymeSecond messengerMammalian tissuesSynthaseFunctional responseNeutrophilsInfectionGMPMacrophagesNeurons
1998
Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note
Smith S, Wheeler M, Weiss R. Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note. Kidney International 1998, 54: 1331-1336. PMID: 9767552, DOI: 10.1046/j.1523-1755.1998.00102.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNitric oxide synthaseNegative predictive accuracyDismutase/catalaseNitrite dipstickTract infectionsPresence of UTINOS cofactorUrine pelletsInducible nitric oxide synthaseHigh negative predictive accuracyHigh positive predictive accuracyUrine screening testsUrine culture resultsNBT reductionInducible NOS activityLeukocyte esterase dipstickNitroblue tetrazolium reductionPositive predictive accuracyNOS inhibitorNOS activityOxide synthaseEarly predictorCulture resultsScreening testBladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder.
Olsson LE, Wheeler MA, Sessa WC, Weiss RM. Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 1203-8. PMID: 9495884.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseUrinary tract infectionIntravesical instillationLocalized inflammatory responseInflammatory responseRat bladderSystemic bacterial lipopolysaccharideInstillation of lipopolysaccharideRat urinary bladderNitric oxide synthaseIL-6 mRNATract infectionsBladder instillationIL-10Urinary nitrateRegulate cytokinesINOS activityIntraperitoneal injectionNOS activityOxide synthaseUrinary bladderImportance of lipopolysaccharideINOS proteinInstillationCGMP levels
1997
Bacterial infection induces nitric oxide synthase in human neutrophils.
Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. Journal Of Clinical Investigation 1997, 99: 110-116. PMID: 9011564, PMCID: PMC507774, DOI: 10.1172/jci119121.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsArginineBacterial InfectionsBlotting, WesternCanavanineCell MembraneCitrullineFemaleGuanidinesHumansImmunohistochemistryIsoenzymesLeukocyte Common AntigensMaleMiddle AgedNeutrophilsNG-Nitroarginine Methyl EsterNitric Oxide SynthaseNitroarginineOmega-N-MethylarginineOrnithinePolymerase Chain ReactionRNA, MessengerSulfonamidesThioureaTrifluoperazineUrinary Tract InfectionsConceptsInducible nitric oxide synthaseUrinary tract infectionNitric oxide synthaseNitric oxide synthase activityTract infectionsOxide synthase activityOxide synthaseInducible nitric oxide synthase activityNitric oxide synthase proteinNitric oxide synthase isoformsInduces nitric oxide synthaseMajor nitric oxide synthase isoformHuman inflammatory cellsHuman inducible nitric oxide synthaseExtended elevationInflammatory cellsProinflammatory functionsAntibiotic treatmentInflammatory processSynthase activityImmunocytochemical evidenceHuman neutrophilsInfectionCalcium independentSynthase isoforms
1996
Nitric oxide synthase induction with renal transplant rejection or infection
Smith S, Wheeler M, Zhang R, Weiss E, Lorber M, Sessa W, Weiss R. Nitric oxide synthase induction with renal transplant rejection or infection. Kidney International 1996, 50: 2088-2093. PMID: 8943494, DOI: 10.1038/ki.1996.533.Peer-Reviewed Original ResearchConceptsUrinary tract infectionRenal transplant patientsNitric oxide synthaseCyclic GMP levelsTransplant patientsTract infectionsNOS activityPost-renal transplantation patientsGMP levelsInducible nitric oxide synthaseNitric oxideRenal allograft rejectionRenal transplant rejectionNitric oxide synthase inductionInducible NOS (iNOS) mRNAUrine of patientsRenal transplantationTransplantation patientsAllograft rejectionTransplant rejectionInducible NOSOxide synthaseNOS mRNAPatientsSynthase inductionUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435.. DOI: 10.1097/00005392-199604000-00098.Peer-Reviewed Original ResearchUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityFemale controlsTract infectionsGMP levelsResults Female patientsCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityAbstract PurposeDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseUrinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections
Smith S, Wheeler M, Foster H, Weiss R. Urinary Nitric Oxide Synthase Activity and Cyclic GMP Levels are Decreased with Interstitial Cystitis and Increased with Urinary Tract Infections. Journal Of Urology 1996, 155: 1432-1435. PMID: 8632605, DOI: 10.1016/s0022-5347(01)66301-8.Peer-Reviewed Original ResearchConceptsUrinary tract infectionCyclic GMP levelsUrinary nitric oxide synthase activityNitric oxide synthase activityInterstitial cystitisOxide synthase activityFemale patientsNOS activityTract infectionsGMP levelsFemale controlsFemale urinary tract infectionCyclic GMP/Certain disease processesIC patientsImmunologic responseUrinary tractSynthase activityDisease processL-argininePatientsNitric oxideL-citrullineGuanylyl cyclaseCyclic GMP
1994
Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine
Smith S, Wheeler M, Weiss R. Nitric oxide synthase: An endogenous source of elevated nitrite in infected urine. Kidney International 1994, 45: 586-591. PMID: 7513034, DOI: 10.1038/ki.1994.76.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNon-infected urineTract infectionsL-arginineUrine nitriteInfected urineUrinary nitric oxide synthase activityNitric oxide synthase activityUrinary nitrite levelsEndogenous sourcesOxide synthase activitySynthase activityMin/Exogenous L-arginineNG-nitroNG-monomethylGriess methodParticulate fractionNitrite levelsUrine fractionsEndogenous productionNitrite productionUrineInfectionElevated nitrite