2017
Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy
Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King‐Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia 2017, 58: 994-1004. PMID: 28398014, DOI: 10.1111/epi.13740.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisSeizure-free periodTemporal lobe epilepsySeizure reductionAdverse eventsLobe epilepsyIntractable mesial temporal lobe epilepsySerious device-related adverse eventsIntractable partial-onset seizuresMedian percent seizure reductionMesial temporal lobe originBilateral mesial temporal lobe epilepsyDevice-related adverse eventsBrain-responsive neurostimulationImplant site infectionPercent seizure reductionPartial-onset seizuresProspective clinical trialsTemporal lobe originVagus nerve stimulationEffective treatment optionPercent of subjectsPreimplantation baselineTemporal sclerosis
2001
Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal Activity
Zaveri H, Duckrow R, De Lanerolle N, Spencer S. Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal Activity. Epilepsia 2001, 42: 725-730. PMID: 11422326, DOI: 10.1046/j.1528-1157.2001.00500.x.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisTemporal lobe epilepsyLobe epilepsySurgical outcomesIntractable temporal lobe epilepsyPoor surgical outcomesGood surgical outcomeMedial temporal structuresMedial temporal lobeDelta band powerTemporal sclerosisRetrospective studyHippocampal tissueBackground EEGSeizure onsetIndividual patientsSurgical proceduresIntracranial monitoringTemporal lobeGamma frequency bandClinical observationsPatientsAnterior hippocampusCell lossSubtypes