2008
AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma.
Gustavson MD, Molinaro AM, Tedeschi G, Camp RL, Rimm DL. AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma. Archives Of Pathology & Laboratory Medicine 2008, 132: 1746-52. PMID: 18976010, DOI: 10.5858/132.11.1746.Peer-Reviewed Original ResearchConceptsThymidylate synthase expressionSynthase expressionColorectal carcinomaSignificant associationDisease-specific survivalColon cancer outcomesColon cancer survivalKey prognostic biomarkersRetrospective cohortNodal statusPrognostic valueColorectal cancerCancer outcomesCancer survivalPathologic classificationPrognostic biomarkerLarge cohortSecond cohortAQUA scoreCytoplasmic expressionNuclear expressionCohortHigh nuclearCytoplasmic ratioFirst cohort
2006
Genetic Differentiation of Appendiceal Tumor Malignancy
Modlin IM, Kidd M, Latich I, Zikusoka MN, Eick GN, Mane SM, Camp RL. Genetic Differentiation of Appendiceal Tumor Malignancy. Annals Of Surgery 2006, 244: 52-60. PMID: 16794389, PMCID: PMC1570599, DOI: 10.1097/01.sla.0000217617.06782.d5.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overAntigens, NeoplasmApoptosis Regulatory ProteinsAppendiceal NeoplasmsAppendicitisBiomarkers, TumorCarcinoid TumorCell Cycle ProteinsChildChromogranin AChromograninsDiagnosis, DifferentialFemaleGene ExpressionGenetic MarkersHistone DeacetylasesHumansImmunohistochemistryMaleMiddle AgedNLR ProteinsNuclear ProteinsNucleosome Assembly Protein 1Repressor ProteinsReverse Transcriptase Polymerase Chain ReactionTrans-ActivatorsConceptsAppropriate surgical managementAppendiceal carcinoidsAppendiceal tumorsSurgical managementMAGE-D2Malignant appendiceal tumorsAppendiceal adenocarcinoidAdenocarcinoid tumorCarcinoid tumorsHistologic evidenceIncidental lesionsColorectal cancerPathologic criteriaQ-RT-PCRAppendiceal tissueGene expressionNormal mucosaTumor potentialCarcinoidsTumor behaviorAppendicitisAdenocarcinoidMorphologic assessmentTumor typesTumor malignancy