2021
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization
Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization. Nature Communications 2021, 12: 4569. PMID: 34315903, PMCID: PMC8316582, DOI: 10.1038/s41467-021-24824-z.Peer-Reviewed Original ResearchConceptsPutative causal genesGenome-wide association studiesUnderstanding of genesIntegrative genomic analysisTrans-ethnic studiesAssociation scanCausal genesGenomic analysisAssociation studiesDiverse ancestral backgroundsGenesSusceptibility genesBiobank JapanHost geneticsProtein levelsAncestral backgroundPathwayExpressionMRNA expressionSplicingRapid progressPhenomeGeneticsHost inflammatory responseCoagulation pathway
2017
ADH1B: From alcoholism, natural selection, and cancer to the human phenome
Polimanti R, Gelernter J. ADH1B: From alcoholism, natural selection, and cancer to the human phenome. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 177: 113-125. PMID: 28349588, PMCID: PMC5617762, DOI: 10.1002/ajmg.b.32523.Peer-Reviewed Original ResearchConceptsHuman phenomeMultiple human tissuesPhenome-wide association studyMolecular functionsGene regulationPhenotypic traitsBioinformatics analysisEvolutionary dataFunctional allelesAssociation studiesMetabolic traitsAlcohol metabolismMolecular pathwaysMultiple molecular pathwaysHuman evolutionPhenomeGenesADH1B geneTraitsComplex mechanismsHuman tissuesMetabolismAllelesADH1BADH1B locus