2015
Modeling the transcriptome of genital tract epithelial cells and macrophages in healthy mucosa versus mucosa inflamed by Chlamydia muridarum infection
Johnson RM, Kerr MS. Modeling the transcriptome of genital tract epithelial cells and macrophages in healthy mucosa versus mucosa inflamed by Chlamydia muridarum infection. Pathogens And Disease 2015, 73: ftv100. PMID: 26519447, PMCID: PMC4732027, DOI: 10.1093/femspd/ftv100.Peer-Reviewed Original ResearchConceptsEpithelial cellsLineage-specific differencesGene expression microarray technologyExpression microarray technologyBone marrow-derived macrophagesMarrow-derived macrophagesAdaptive immunityReproductive tract epitheliumCell line responsePrincipal cell typesMicroarray technologyIntracellular bacteriaChlamydia-specific T cellsGenital tract epithelial cellsCell typesBacterial replicationChlamydia muridarum infectionMHC class II moleculesEpithelial requirementTract epithelial cellsClass II moleculesInnate defenseHost defenseCoinhibitory ligandsInflamed/
2010
Chlamydia-Specific CD4 T Cell Clones Control Chlamydia muridarum Replication in Epithelial Cells by Nitric Oxide-Dependent and -Independent Mechanisms
Jayarapu K, Kerr M, Ofner S, Johnson RM. Chlamydia-Specific CD4 T Cell Clones Control Chlamydia muridarum Replication in Epithelial Cells by Nitric Oxide-Dependent and -Independent Mechanisms. The Journal Of Immunology 2010, 185: 6911-6920. PMID: 21037093, PMCID: PMC3073083, DOI: 10.4049/jimmunol.1002596.Peer-Reviewed Original ResearchConceptsCD4 T-cell clonesT cell clonesEpithelial NO productionCD4 T cellsChlamydia replicationCell clonesEpithelial cellsT cellsNO productionReproductive tract epithelial cellsT cell-mediated controlT-cell depletion studiesCell depletion studiesCell-mediated controlHuman reproductive tractT cell degranulationMHC class IIMurine genital tractTract epithelial cellsInfected epithelial cellsEpithelial tumor cell linesIntracellular bacterial pathogenBacterial clearanceCell degranulationGenital tract
2009
Chlamydia muridarum-Specific CD4 T-Cell Clones Recognize Infected Reproductive Tract Epithelial Cells in an Interferon-Dependent Fashion
Jayarapu K, Kerr MS, Katschke A, Johnson RM. Chlamydia muridarum-Specific CD4 T-Cell Clones Recognize Infected Reproductive Tract Epithelial Cells in an Interferon-Dependent Fashion. Infection And Immunity 2009, 77: 4469-4479. PMID: 19667042, PMCID: PMC2747947, DOI: 10.1128/iai.00491-09.Peer-Reviewed Original ResearchConceptsCD4 T-cell clonesT cell clonesReproductive tract epithelial cellsCD4 T cell interactionsT cell activationGenital tract infectionCD4 T cellsTract epithelial cellsT cell interactionsEpithelial cellsTract infectionsMHC-IIT cellsChlamydia muridarum Genital Tract InfectionChlamydia-specific CD4 T cellsMajor histocompatibility complex (MHC) class II moleculesIFN-gamma-induced upregulationCell surface MHC-IIExperimental mouse modelSurface MHC-IIClass II moleculesReproductive tract epitheliumTiming of recognitionFuture vaccine developmentChlamydia replication