2014
An atypical CD8 T‐cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin‐13
Johnson RM, Kerr MS, Slaven JE. An atypical CD8 T‐cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin‐13. Immunology 2014, 142: 248-257. PMID: 24428415, PMCID: PMC4008232, DOI: 10.1111/imm.12248.Peer-Reviewed Original ResearchConceptsGenital tract infectionCD8 T cellsCD8 T cell responsesCD8 T cell clonesT cell responsesTract infectionsT cell clonesT cellsProtective immunityInterleukin-13T helper type 1 cell responsesC. muridarum genital tract infectionChlamydia muridarum Genital Tract InfectionMHC class Ia moleculesCD4 T cellsRole of TNFAntigen-presenting cellsTumor necrosis factorReproductive tract epitheliumClass Ia moleculesCD8 clonesCD8 levelsChlamydia replicationNaive splenocytesIntracellular bacterial pathogen
2013
Perforin Is Detrimental to Controllinγ C. muridarum Replication In Vitro, but Not In Vivo
Johnson RM, Kerr MS, Slaven JE. Perforin Is Detrimental to Controllinγ C. muridarum Replication In Vitro, but Not In Vivo. PLOS ONE 2013, 8: e63340. PMID: 23691028, PMCID: PMC3653963, DOI: 10.1371/journal.pone.0063340.Peer-Reviewed Original ResearchConceptsGenital tract infectionPerforin knockout miceChlamydia replicationTract infectionsEpithelial cellsKnockout miceC. muridarum genital tract infectionChlamydia muridarum Genital Tract InfectionClearance mechanismsVivo clearance mechanismsCD4 T cellsT cell mechanismsT cell-epithelial cell interactionsT cell degranulationNitric oxide productionBacterial clearanceEpithelial productionCell degranulationT cellsSingle-gene knockout miceWeek 7Oxide productionPerforinNitric oxideInfection
2010
Chlamydia-Specific CD4 T Cell Clones Control Chlamydia muridarum Replication in Epithelial Cells by Nitric Oxide-Dependent and -Independent Mechanisms
Jayarapu K, Kerr M, Ofner S, Johnson RM. Chlamydia-Specific CD4 T Cell Clones Control Chlamydia muridarum Replication in Epithelial Cells by Nitric Oxide-Dependent and -Independent Mechanisms. The Journal Of Immunology 2010, 185: 6911-6920. PMID: 21037093, PMCID: PMC3073083, DOI: 10.4049/jimmunol.1002596.Peer-Reviewed Original ResearchConceptsCD4 T-cell clonesT cell clonesEpithelial NO productionCD4 T cellsChlamydia replicationCell clonesEpithelial cellsT cellsNO productionReproductive tract epithelial cellsT cell-mediated controlT-cell depletion studiesCell depletion studiesCell-mediated controlHuman reproductive tractT cell degranulationMHC class IIMurine genital tractTract epithelial cellsInfected epithelial cellsEpithelial tumor cell linesIntracellular bacterial pathogenBacterial clearanceCell degranulationGenital tract
2009
Chlamydia muridarum-Specific CD4 T-Cell Clones Recognize Infected Reproductive Tract Epithelial Cells in an Interferon-Dependent Fashion
Jayarapu K, Kerr MS, Katschke A, Johnson RM. Chlamydia muridarum-Specific CD4 T-Cell Clones Recognize Infected Reproductive Tract Epithelial Cells in an Interferon-Dependent Fashion. Infection And Immunity 2009, 77: 4469-4479. PMID: 19667042, PMCID: PMC2747947, DOI: 10.1128/iai.00491-09.Peer-Reviewed Original ResearchConceptsCD4 T-cell clonesT cell clonesReproductive tract epithelial cellsCD4 T cell interactionsT cell activationGenital tract infectionCD4 T cellsTract epithelial cellsT cell interactionsEpithelial cellsTract infectionsMHC-IIT cellsChlamydia muridarum Genital Tract InfectionChlamydia-specific CD4 T cellsMajor histocompatibility complex (MHC) class II moleculesIFN-gamma-induced upregulationCell surface MHC-IIExperimental mouse modelSurface MHC-IIClass II moleculesReproductive tract epitheliumTiming of recognitionFuture vaccine developmentChlamydia replication