2023
Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2020
Data Visualization Tools of Tobacco Product Use Patterns, Transitions and Sex Differences in the PATH Youth Data
Gueorguieva R, Buta E, Simon P, Krishnan-Sarin S, O’Malley S. Data Visualization Tools of Tobacco Product Use Patterns, Transitions and Sex Differences in the PATH Youth Data. Nicotine & Tobacco Research 2020, 22: 1901-1908. PMID: 32219313, PMCID: PMC7542650, DOI: 10.1093/ntr/ntaa056.Peer-Reviewed Original ResearchConceptsTobacco product use patternsMultiple tobacco product useProduct use patternsTobacco product useE-cigarettesProduct useTobacco productsHookah useWave 1Wave 2Common tobacco productsTobacco use patternsE-cigarette useSex differencesInitiation of usePatterns of useHealth StudyAdolescent girlsYear old youthRelative frequencyUnweighted frequenciesCigarettesOlder youthUse patternsPopulation AssessmentTransitions across tobacco use profiles among adolescents: results from the Population Assessment of Tobacco and Health (PATH) study waves 1 and 2
Simon P, Buta E, Gueorguieva R, Kong G, Morean ME, Camenga D, Bold KW, Krishnan‐Sarin S. Transitions across tobacco use profiles among adolescents: results from the Population Assessment of Tobacco and Health (PATH) study waves 1 and 2. Addiction 2020, 115: 740-747. PMID: 31618491, PMCID: PMC7361287, DOI: 10.1111/add.14828.Peer-Reviewed Original ResearchConceptsUse of cigarettesE-cigarettesHealth Study Waves 1Wave 1US youthProbability of progressionUsers of cigarettesNon-institutionalized populationTobacco use statusTobacco use profilesSocio-demographic predictorsRate of useCurrent useProspective surveyMore tobacco productsLatent transition analysisSmokeless tobaccoNicotine productsHealth StudyUS civilianParental education levelTobacco productsCigarettesPopulation AssessmentUse statusDifferential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers
Jensen KP, Valentine G, Gueorguieva R, Sofuoglu M. Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers. Psychopharmacology 2020, 237: 1359-1369. PMID: 31996940, PMCID: PMC7386792, DOI: 10.1007/s00213-020-05463-6.Peer-Reviewed Original ResearchConceptsSubjective drug effectsBlood pressureHeart rateDrug effectsSmoking urgesDifferential effectsBlood pressure increaseBody weight doseEffects of nicotineDelivery rateGreater heart rateAmount of nicotineWeight doseFemale smokersTobacco smokersAbstinence symptomsNicotine doseSaline infusionInfusion protocolNon-treatment seekingTobacco cigarettesHuman studiesInfusionTobacco productsNicotine
2019
Tobacco use increases risk of food insecurity: An analysis of continuous NHANES data from 1999 to 2014
Mayer M, Gueorguieva R, Ma X, White MA. Tobacco use increases risk of food insecurity: An analysis of continuous NHANES data from 1999 to 2014. Preventive Medicine 2019, 126: 105765. PMID: 31260724, DOI: 10.1016/j.ypmed.2019.105765.Peer-Reviewed Original ResearchConceptsLow food securityTobacco useTobacco productsNutrition Examination Survey dataSingle product useAlternative tobacco productsUse of cigarettesMagnitude of associationLogistic regression modelsMultiple tobacco productsMultinomial logistic regression modelsFood insecurityNational HealthHigh prevalenceHealth disparity issuesNHANES dataOnly cigarettesSignificant associationTobacco product typesProduct useHealth risksCigarettesAssociationRegression modelsOddsModulation of “Protective” Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-cigarettes
DeVito EE, Jensen KP, O’Malley S, Gueorguieva R, Krishnan-Sarin S, Valentine G, Jatlow PI, Sofuoglu M. Modulation of “Protective” Nicotine Perception and Use Profile by Flavorants: Preliminary Findings in E-cigarettes. Nicotine & Tobacco Research 2019, 22: 771-781. PMID: 30995302, PMCID: PMC7368338, DOI: 10.1093/ntr/ntz057.Peer-Reviewed Original ResearchConceptsSubjective drug effectsNicotine-containing e-liquidsSelf-administered more nicotineAversive effectsSingle testing dayE-cigarettesSelf-reported preferencesE-cigarette appealRs16969968 genotypePreliminary findingsUnflavored e-liquidsIndividual differencesDrug effectsAd libitumE-liquidsAversive actionsTobacco productsNicotine effectsLow-risk groupNicotine-free e-liquidsPalatable flavorAversivenessTesting daysNicotinic acetylcholine receptor subunit genesNumber of puffs
2018
A fMRI study on the impact of advertising for flavored e-cigarettes on susceptible young adults
Garrison KA, O'Malley SS, Gueorguieva R, Krishnan-Sarin S. A fMRI study on the impact of advertising for flavored e-cigarettes on susceptible young adults. Drug And Alcohol Dependence 2018, 186: 233-241. PMID: 29626776, PMCID: PMC5948598, DOI: 10.1016/j.drugalcdep.2018.01.026.Peer-Reviewed Original ResearchConceptsTobacco-flavored e-cigarettesE-cigarettesE-cigarette advertisementsHealth warningsBrain biomarkersWarning labelsYoung adultsSusceptible young adultsE-cigarette health risksE-cigarette conditionsFuture e-cigarette useE-cigarette useFlavored e-cigarettesCigarette conditionCollege-aged young adultsRegular cigarettesNucleus accumbensTobacco productsNucleus accumbens (NAc) activityFMRI studyPositive associationControl imagesHealth risksPoor memoryBiomarkers
2017
Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes
Krishnan-Sarin S, Green BG, Kong G, Cavallo DA, Jatlow P, Gueorguieva R, Buta E, O’Malley S. Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes. Drug And Alcohol Dependence 2017, 180: 193-199. PMID: 28915478, PMCID: PMC5659733, DOI: 10.1016/j.drugalcdep.2017.07.044.Peer-Reviewed Original ResearchConceptsAd lib useE-cigarettesE-cigarette usersStimulant effectsNicotine concentrationsNicotine-containing e-cigarettesNicotine withdrawal symptomsMenthol concentrationRandom counterbalanced orderPositive rewarding effectsNicotine exposureNicotine withdrawalWithdrawal symptomsRewarding effectsMenthol glucuronideHigh menthol concentrationLow dosesNicotine levelsTobacco productsNicotineCounterbalanced order