2013
Stress as a Common Risk Factor for Obesity and Addiction
Sinha R, Jastreboff AM. Stress as a Common Risk Factor for Obesity and Addiction. Biological Psychiatry 2013, 73: 827-835. PMID: 23541000, PMCID: PMC3658316, DOI: 10.1016/j.biopsych.2013.01.032.BooksConceptsNeurobiology of stressHP foodsIncentive salienceFood motivationIntegrative heuristic modelFood-related motivationDevelopment of addictionBiology of stressNeural mechanismsNeurobiological mechanismsAddiction relapsePalatable foodAddictive drugsAllostatic loadMotivationRisk factorsSalienceHigh levelsNeurobiologyHeuristic modelEnergy homeostasisWeight gainAddictionFuture directionsDopaminergic activity
2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsGlucose levelsHyperinsulinemic euglycemic-hypoglycemic clampsBrain regionsFunctional MRIMedial prefrontal cortexMedial prefrontal cortex activationRisk of overeatingLevels of glucosePostprandial reductionPrefrontal cortex activationObese subjectsNonobese individualsMild hypoglycemiaWorldwide epidemicCortex activationPrefrontal cortexFood cuesFood motivationFood stimuliNeural controlObesityInhibitory controlBehavioral measuresVisual cues