Featured Publications
A precision medicine approach to metabolic therapy for breast cancer in mice
Akingbesote ND, Norman A, Zhu W, Halberstam AA, Zhang X, Foldi J, Lustberg MB, Perry RJ. A precision medicine approach to metabolic therapy for breast cancer in mice. Communications Biology 2022, 5: 478. PMID: 35595952, PMCID: PMC9122928, DOI: 10.1038/s42003-022-03422-9.Peer-Reviewed Original ResearchConceptsPrecision medicine approachBreast cancerSodium-glucose transport protein 2 inhibitorsBreast tumorsMedicine approachCanonical insulinSGLT2 inhibitor dapagliflozinEfficacy of paclitaxelBreast tumor-bearing miceTumor glucose uptakeTumor-bearing miceChemotherapy correlatesNeoadjuvant approachNeoadjuvant settingPaclitaxel chemotherapyInhibitor dapagliflozinSGLT2 inhibitorsProlonging survivalAntihyperglycemic drugsPotential adjuvantMetabolic therapyDapagliflozinTumorsDriver mutationsGlucose uptake
2023
The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer
Ramshankar G, Liu R, Perry R. The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer. PLOS ONE 2023, 18: e0292678. PMID: 37819900, PMCID: PMC10566702, DOI: 10.1371/journal.pone.0292678.Peer-Reviewed Original ResearchConceptsL-type amino acid transporter 1Menopausal statusPrognostic effectLAT1 expressionBreast cancerTumor proliferationAmino acid transporter LAT1Immune cell infiltrationHigh LAT1 expressionAmino acid transporter 1Worse patient outcomesKaplan-Meier modelBreast cancer prognosisPatient survival probabilityPositron emission tomography-computed tomography (PET-CT) imagesSpecific essential amino acidsClinical factorsClinical parametersCell infiltrationPatient outcomesSystemic metabolismCancer prognosisBody compositionProliferative featuresCancer typesA review of the impact of energy balance on triple-negative breast cancer
Akingbesote N, Owusu D, Liu R, Cartmel B, Ferrucci L, Zupa M, Lustberg M, Sanft T, Blenman K, Irwin M, Perry R. A review of the impact of energy balance on triple-negative breast cancer. JNCI Monographs 2023, 2023: 104-124. PMID: 37139977, DOI: 10.1093/jncimonographs/lgad011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTriple-negative breast cancerInterventional studyBreast cancerCancer treatmentClinical interventional studyClinical observationalImmune activationCancer outcomesCancer careClinical studiesOverall healthEnergy intakeNarrative reviewCancer cellsEnergy expenditureCancerTreatmentEnergy balanceOutcomesExerciseReviewDetrimental effectsImmunotherapyStudyIntakeThe impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors
Liu R, Ospanova S, Perry R. The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors. PLOS ONE 2023, 18: e0281252. PMID: 36735704, PMCID: PMC9897541, DOI: 10.1371/journal.pone.0281252.Peer-Reviewed Original ResearchConceptsBreast cancer prognosisBreast cancerFatty acid metabolismCancer prognosisCarnitine palmitoyltransferase 1 expressionHigh-risk breast cancerPre-menopausal patientsAcid metabolismPatient survival probabilityPositron emission tomography-computed tomography (PET-CT) imagesFatty acid oxidationMenopausal statusAnthropometric factorsPathogenic factorsCPT1A expressionRate-limiting enzymeObesityProtective relationshipCancerSurvival probabilityCancer Imaging ArchivePotential rolePatientsPrognosisAcid oxidation
2020
The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer
Leitner BP, Perry RJ. The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer. JNCI Cancer Spectrum 2020, 4: pkaa007. PMID: 32368718, PMCID: PMC7190208, DOI: 10.1093/jncics/pkaa007.Peer-Reviewed Original ResearchBody mass indexTumor glucose uptakeLung cancerGlucose uptakeGlucose metabolismNon-small cell lung cancerHigher body mass indexObesity-cancer linkImpact of obesityCell lung cancerSquamous cell carcinomaSoft tissue sarcomasAltered glucose metabolismPoor clinical prognosisTumor glucose metabolismMass indexPoor outcomeTissue sarcomasCell carcinomaTomography/Clinical prognosisBreast cancerProtective effectObesityCancer