2012
Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme
Dessau M, Goldhill D, McBride R, Turner PE, Modis Y. Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme. PLOS Genetics 2012, 8: e1003102. PMID: 23209446, PMCID: PMC3510033, DOI: 10.1371/journal.pgen.1003102.Peer-Reviewed Original ResearchConceptsFitness tradeoffsPleiotropic mutationMolecular basisRNA virusesSingle amino acid substitutionAmino acid substitutionsIndividual point mutationsEvolutionary tugPleiotropic phenotypesExperimental evolutionAntagonistic pleiotropyEvolutionary biologyProtein functionLytic transglycosylaseNatural selectionProtein P5Reproductive fitnessStructural biologySelective pressureMutational substitutionsHeat shockProtein structureCapsid assemblyAcid substitutionsBacteriophage Φ6
2006
Pleiotropic Costs of Niche Expansion in the RNA Bacteriophage Φ6
Duffy S, Turner PE, Burch CL. Pleiotropic Costs of Niche Expansion in the RNA Bacteriophage Φ6. Genetics 2006, 172: 751-757. PMID: 16299384, PMCID: PMC1456241, DOI: 10.1534/genetics.105.051136.Peer-Reviewed Original ResearchConceptsNiche expansionAntagonistic pleiotropyCosts of generalismVaried ecological conditionsRNA virus phi6Standard laboratory hostRNA bacteriophage φ6Host range mutantsPleiotropic costsHost shiftsPseudomonas hostsFitness costsGenetic basisGenetic dataHost attachmentHost rangeExperimental model systemAdaptive mutationsHost typeNonsynonymous mutationsEcological conditionsOriginal hostRNA virusesBacteriophage Φ6Generalism