2023
Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study
Levasseur J, Fikse L, Mauguen A, Killinger J, Karam O, Nellis M. Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study. Pediatric Critical Care Medicine 2023, 24: e602-e610. PMID: 37678406, PMCID: PMC10843653, DOI: 10.1097/pcc.0000000000003374.Peer-Reviewed Original ResearchConceptsProspective cohort studyBleeding episodesSevere bleedingIll childrenCohort studyCell transplantIncidence rateLaboratory valuesMinimal bleedingRadiation therapySingle-center prospective cohort studyAssociated Patient CharacteristicsHigher PICU mortalityNew bleeding episodesOnly laboratory valueHematopoietic cell transplantCritically Ill ChildrenLow platelet countSevere bleeding episodesStem cell transplantPatient demographic dataSpecialized cancer hospitalModerate bleeding episodesYears of ageLonger PICUFirst nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO)
Cousin V, Rodriguez-Vigouroux R, Karam O, Rimensberger P, Posfay-Barbe K. First nosocomial infections in children supported by veno-arterial extracorporeal membrane oxygenation (VA-ECMO). BMC Pediatrics 2023, 23: 89. PMID: 36823601, PMCID: PMC9948414, DOI: 10.1186/s12887-023-03908-3.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolCross InfectionExtracorporeal Membrane OxygenationHospital MortalityHumansInfantMaleRetrospective StudiesTreatment OutcomeConceptsVA-ECMO supportPediatric intensive care unitMedian timeClinical signsMedian PICU LOSNosocomial infection occurrenceUrinary tract infectionVentilator-associated pneumoniaExtracorporeal membrane oxygenationIntensive care unitPaucity of dataPICU lengthPICU LOSRefractory shockVA-ECMOTract infectionsMedian ageMembrane oxygenationSternotomy infectionsCare unitRetrospective studySevere infectionsFirst infectionMortality rateInfection occurrence
2021
Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)
Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola‐Visner M, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Study‐IV‐Pediatric F. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III). Transfusion 2021, 61: 2589-2600. PMID: 34455598, DOI: 10.1111/trf.16626.Peer-Reviewed Original ResearchConceptsInternational normalized ratioBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIINational Heart LungTransfusion practicePediatric oncologyRecipient EpidemiologyHSCT patientsPlasma transfusionRed blood cellsPlatelet countHeart LungHematopoietic stem cell transplantation patientsHematopoietic stem cell transplant patientsMedian international normalized ratioStem cell transplant patientsStem cell transplantation patientsLower INR valuesPre-transfusion HbMedian platelet countMulticenter retrospective studyCell transplant patientsCell transplantation patientsStudy IIIAcute myeloid leukemiaTransfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database
Hanson SJ, Karam O, Birch R, Goel R, Patel RM, Sola-Visner M, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Nellis ME, Lung A. Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database. Pediatric Critical Care Medicine 2021, 22: 978-987. PMID: 34261944, PMCID: PMC8570986, DOI: 10.1097/pcc.0000000000002805.Peer-Reviewed Original ResearchMeSH KeywordsBlood Component TransfusionBlood TransfusionCardiac Surgical ProceduresCardiopulmonary BypassChildHumansPlatelet TransfusionRetrospective StudiesConceptsCongenital heart diseaseBiventricular surgeryCardiopulmonary bypass surgeryHeart diseaseMedian internationalBypass surgeryMembrane oxygenationPlatelet countBlood componentsVentricular surgeryHemoglobin valuesBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIHigher median platelet countNormal international normalized ratioIntraoperative platelet transfusionLimited physiologic reserveMultiple blood productsPretransfusion platelet countU.S. hospitalsMedian platelet countBlood component transfusionBlood component usageExtracorporeal membrane oxygenationInternational normalized ratioFactors Associated With Initiation of Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Population: An International Survey
Nguyen DA, De Mul A, Hoskote AU, Cogo P, da Cruz EM, Erickson S, Lasa JJ, Thiagarajan RR, Bembea MM, Karam O, ESPNIC A. Factors Associated With Initiation of Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Population: An International Survey. ASAIO Journal 2021, 68: 413-418. PMID: 34074851, DOI: 10.1097/mat.0000000000001495.Peer-Reviewed Original ResearchMeSH KeywordsCardiopulmonary ResuscitationChildExtracorporeal Membrane OxygenationHeart ArrestHumansInfant, NewbornIntensive Care Units, PediatricRetrospective StudiesConceptsExtracorporeal cardiopulmonary resuscitationCPR durationCardiac arrestCardiopulmonary resuscitationIntensive care unit locationPediatric critical care physiciansCPR qualityPostoperative cardiac surgeryChronic respiratory failureMultiple organ failurePediatric extracorporeal cardiopulmonary resuscitationDuration of CPRPediatric critical care environmentCritical care physiciansDoses of adrenalineFormer preterm childrenLocation of arrestUnwitnessed cardiac arrestExtracorporeal membrane oxygenation teamBetter CPR qualityCritical care environmentECPR initiationECMO initiationRespiratory failureClinical determinantsTransfusion practices in a large cohort of hospitalized children
Nellis ME, Goel R, Hendrickson JE, Birch R, Patel RM, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Sola‐Visner M, Josephson CD, Karam O, Study‐IV‐Pediatric F. Transfusion practices in a large cohort of hospitalized children. Transfusion 2021, 61: 2042-2053. PMID: 33973660, DOI: 10.1111/trf.16443.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood Component TransfusionBlood TransfusionChildChild, PreschoolDatasets as TopicDiagnosis-Related GroupsFemaleHospital MortalityHospitals, CommunityHospitals, TeachingHumansInfantInfant, NewbornInpatientsMaleProcedures and Techniques UtilizationRetrospective StudiesUnited StatesConceptsRBC transfusionCardiopulmonary bypassTransfusion practiceHospitalized childrenInpatient encountersBlood componentsLarge cohortHospital settingBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIPatient blood management initiativesDiagnostic categoriesFrequency of transfusionInstitutional transfusion guidelinesCohort of patientsInternational normalized ratioPercent of encountersNational Heart LungPediatric hospital settingYears of ageSubset of childrenRecipient EpidemiologyTransfusion guidelinesRed blood cellsEntire cohort
2020
Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis
Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticoagulantsBlood CoagulationExtracorporeal Membrane OxygenationHemorrhageHeparinHumansRetrospective StudiesConceptsAnticoagulation strategiesMortality rateThrombotic eventsObservational studySystematic reviewProportion of bleedingType of ECMOExtracorporeal membrane oxygenationMultiple electronic databasesLower mortality rateMembrane oxygenationPatientsElectronic databasesECMOThrombosisSignificant differencesXaBleedingReviewMortalityStudy
2019
Anemia at Discharge From the PICU: A Bicenter Descriptive Study.
Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPICU admissionPICU dischargeRisk of anemiaCritical illnessRisk markersHigher C-reactive protein levelsInotropic/vasopressor supportC-reactive protein levelsWorld Health Organization criteriaMedian hemoglobin levelRetrospective cohort studyElectronic medical recordsVasopressor supportPlasma transfusionCohort studyCreatinine levelsMultivariate adjustmentAnemic childrenHemoglobin levelsMechanical ventilationAnemia statusOrganization criteriaMedical recordsIll children
2016
Are Scores Reliable in Predicting the Need for Surgery and Mortality in Necrotizing Enterocolitis?
Arni D, Karam O, Vidal I, Rimensberger PC, Hanquinet S, Wildhaber BE. Are Scores Reliable in Predicting the Need for Surgery and Mortality in Necrotizing Enterocolitis? European Journal Of Pediatric Surgery 2016, 27: 330-335. PMID: 27706524, DOI: 10.1055/s-0036-1593382.Peer-Reviewed Original ResearchConceptsStage IIBell stage IINEC stage IIManagement of childrenNecrotizing enterocolitisPatient cohortSingle institutionClinical usefulnessNEC scoreRetrospective analysisStage IIIAcuity scoresSurgeryPatientsMortalityKappa statisticsEnterocolitisScoresCohortOutcomesDifferent scoresChildrenKappa indexPotential Pediatric Organ Donors After Cardiac Death
Pregernig A, Karam O. Potential Pediatric Organ Donors After Cardiac Death. Transplantation Proceedings 2016, 48: 2588-2591. PMID: 27788786, DOI: 10.1016/j.transproceed.2016.06.049.Peer-Reviewed Original ResearchConceptsWithdrawal of careOrgan donorsAgonal timeMaximal resuscitationCardiac deathPediatric populationNeonatal intensive care unitOrgan donationBrain-dead childrenIntensive care unitOrgan donor poolTransplant waiting listPediatric organ donorPotential organ donorsOrgan donation programsMedical contraindicationsCare unitRetrospective studyDonor poolWaiting listDonation programDonor populationCareChildrenResuscitation