2021
Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients
Tarquinio KM, Karsies T, Shein SL, Beardsley A, Khemani R, Schwarz A, Smith L, Flori H, Karam O, Cao Q, Haider Z, Smirnova E, Serrano MG, Buck GA, Willson DF. Airway microbiome dynamics and relationship to ventilator‐associated infection in intubated pediatric patients. Pediatric Pulmonology 2021, 57: 508-518. PMID: 34811963, PMCID: PMC8809006, DOI: 10.1002/ppul.25769.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolHumansMicrobiotaPneumonia, Ventilator-AssociatedRespiration, ArtificialTracheaUnited StatesVentilators, MechanicalConceptsVentilator-associated infectionDays of intubationAirway microbiomeSerial tracheal aspirate samplesPediatric intensive care unitIntensive care unitIntubated pediatric patientsTracheal aspirate samplesTracheal microbiomePediatric patientsCare unitClinical parametersIntubation periodClinical variablesAntibiotic treatmentVentilated subjectsAspirate samplesInfection scoreMedian numberSubject demographicsPorphyromonadaceae familyMicrobiome patternsIntubationVeillonella atypicaPatientsCompliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*
Karsies T, Tarquinio K, Shein SL, Beardsley AL, Prentice E, Karam O, Fontela P, Moore-Clingenpeel M, Willson DF. Compliance With an Antibiotic Guideline for Suspected Ventilator-Associated Infection: The Ventilator-Associated INfection (VAIN2) Study*. Pediatric Critical Care Medicine 2021, 22: 859-869. PMID: 33965989, DOI: 10.1097/pcc.0000000000002761.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsChildChild, PreschoolGuideline AdherenceHumansProspective StudiesRespiration, ArtificialUnited StatesVentilators, MechanicalConceptsVentilator-associated infectionPositive respiratory culturesRespiratory culturesAntibiotic continuationPhase 3 subjectsRespiratory culture resultsVentilator-Associated InfectionsObservational cohort studyOverall study populationBaseline data collectionPhase 1Antibiotic discontinuationAntibiotic recommendationsAntibiotic guidelinesAntibiotic decisionsCohort studyGuideline adherenceMicrobiologic dataIllness severityMechanical ventilationAntibiotic managementRespiratory secretionsAntibiotic utilizationConsensus guidelinesAntibiotic treatment
2014
New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance
Grazioli S, Karam O, Rimensberger PC. New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance. Respiratory Care 2014, 60: 363-370. PMID: 25406342, DOI: 10.4187/respcare.03048.Peer-Reviewed Original ResearchConceptsVolume-targeted modesInfant's conditionNeonatal ventilatorsPre-term infantsRespiratory system conditionsHigh-frequency ventilationExpiratory tidal volumeLung mechanical propertiesTerm infantsPreclinical dataVentilator settingsFrequency ventilationClinical conditionsLung characteristicsTidal volumeClinical relevanceInfant settingsVentilatorFurther studies
2007
Noise levels during nCPAP are flow-dependent but not device-dependent
Karam O, Donatiello C, Van Lancker E, Chritin V, Pfister RE, Rimensberger PC. Noise levels during nCPAP are flow-dependent but not device-dependent. Archives Of Disease In Childhood Fetal & Neonatal 2007, 93: f132. PMID: 18089628, DOI: 10.1136/adc.2007.129098.Peer-Reviewed Original ResearchConceptsNasal continuous positive airway pressureCare unitContinuous positive airway pressurePediatric critical care unitNeonatal intensive care unitOutcomes of infantsPositive airway pressureRespiratory distress syndromeIntensive care unitCritical care unitsAirway pressureDistress syndromeMechanical ventilationPremature infantsNeonatal careNoxious exposuresOral cavityOccupational limitsInfantsLevelsSyndromeCare