2024
Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
Nellis M, Moynihan K, Sloan S, Delaney M, Kneyber M, DiGeronimo R, Alexander P, Muszynski J, Gehred A, Lyman E, Karam O, in collaboration with the Pediatric Critical Care Blood Research Network A. Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e25-e34. PMID: 38959357, PMCID: PMC11216389, DOI: 10.1097/pcc.0000000000003493.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationProphylactic transfusion strategyTransfusion strategyMembrane oxygenationProphylactic blood product transfusionsPediatric extracorporeal membrane oxygenationConsensus statementPediatric ECMO patientsBlood product transfusionExpert consensus statementPractice statementsStandardized data extraction formProphylactic transfusionECMO patientsProduct transfusionModified Delphi consensusWeak recommendationConsensus conferenceRecommendations AssessmentData extraction formDelphi processStudy assessed useModified Delphi processLiterature searchDelphi consensusClinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia.
Labarinas S, Norbisrath K, Johnson D, Meliones J, Greenleaf C, Salazar J, Karam O. Clinical outcomes in critically ill children on extracorporeal membrane oxygenation with severe thrombocytopenia. Perfusion 2024, 2676591241247981. PMID: 38626382, DOI: 10.1177/02676591241247981.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationExtracorporeal membrane oxygenation daysCritically ill childrenSevere thrombocytopeniaPlatelet countPlatelet transfusionsMembrane oxygenationIll childrenMortality rateDuration of extracorporeal membrane oxygenationAssociated with in-hospital mortality ratesExtracorporeal membrane oxygenation durationSingle-center retrospective studyPlatelet transfusion strategyFrequent platelet transfusionsIn-hospital mortality rateAssociated with bleedingTransfusion strategyAssociated with higher proportionsMedian weightMulticenter studyRetrospective studyClinical outcomesOn-ECMOThrombocytopenia
2023
Anticoagulation and hemostasis on extracorporeal membrane oxygenation
Carmona C, Nellis M, Karam O. Anticoagulation and hemostasis on extracorporeal membrane oxygenation. Current Opinion In Pediatrics 2023, 35: 297-302. PMID: 36974451, DOI: 10.1097/mop.0000000000001247.Peer-Reviewed Original ResearchConceptsHemostatic transfusionsMembrane oxygenationPlatelet transfusionsProspective randomized trialsOptimal anticoagulation strategyExtracorporeal membrane oxygenationPlatelet transfusion strategyRecent systematic reviewHemostatic changesAnticoagulation strategiesFrequent complicationMost patientsThrombotic complicationsTransfusion strategyRandomized trialsCareful titrationObservational studyTransfusionSystematic reviewAnticoagulationECMOComplicationsBleedingTwo-fold decreaseRisk
2022
Transfusion Strategies in the 21st Century A Case-Based Narrative Report
Shenker J, Abuelhija H, Karam O, Nellis M. Transfusion Strategies in the 21st Century A Case-Based Narrative Report. Critical Care Clinics 2022, 39: 287-298. PMID: 36898774, DOI: 10.1016/j.ccc.2022.09.005.Peer-Reviewed Original ResearchPlasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Lieberman L, Karam O, Stanworth SJ, Goobie SM, Crighton G, Goel R, Lacroix J, Nellis ME, Parker RI, Steffen K, Stricker P, Valentine SL, Steiner ME, Network A. Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e37-e49. PMID: 34989704, PMCID: PMC8769367, DOI: 10.1097/pcc.0000000000002857.Peer-Reviewed Original ResearchConceptsAnemia EXpertise Initiative-Control/AvoidanceAcute liver diseaseLiver transplantationExpert consensus statementLiver diseaseIntravascular coagulationIll neonatesPlatelet transfusionsIll childrenConsensus statementSystematic reviewLos Angeles Appropriateness MethodExpert-based statementsAcute liver failurePlatelet transfusion strategyDevelopment/UniversityCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion strategyLiver failureTransfusion managementAppropriateness MethodTransfusionSepsis
2020
Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation.
Karam O, Goel R, Dalton H, Nellis ME. Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation. Critical Care Medicine 2020, 48: e698-e705. PMID: 32697511, DOI: 10.1097/ccm.0000000000004417.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkChest tube outputMembrane oxygenationHemostatic transfusionsRBC transfusionTransfusion doseExtracorporeal membrane oxygenation daysLarge observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkTube outputPlatelet transfusion doseObservational cohort studyHuman Development Collaborative Pediatric Critical Care Research NetworkInternational normalized ratioTotal platelet countPartial thromboplastin timeAntithrombin levelsCohort studyConsecutive childrenTransfusion strategyChest tubePlatelet countHemostatic testingHow 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey.
Demaret P, Karam O, Labreuche Bst J, Chiusolo F, Mayordomo Colunga J, Erickson S, Nellis ME, Perez MH, Ray S, Tucci M, Willems A, Duhamel A, Lebrun F, Loeckx I, Mulder A, Leteurtre S. How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey. Pediatric Critical Care Medicine 2020, 21: e342-e353. PMID: 32217901, DOI: 10.1097/pcc.0000000000002307.Peer-Reviewed Original ResearchConceptsManagement of anemiaPICU dischargePediatric intensivistsTransfusion thresholdCardiac surgeryHemoglobin levelsHemorrhagic shockPrescription of erythropoietinRestrictive transfusion strategyCyanotic heart diseaseCraniofacial surgeryVentricular dysfunctionCritical illnessTransfusion strategyRBC transfusionAcute phaseHeart diseaseSupplemental ironThird of respondentsAnemiaAppropriate managementIntensivistsSurgeryOptimal managementPolytrauma
2019
Transfusion in children with acute respiratory distress syndrome.
François T, Emeriaud G, Karam O, Tucci M. Transfusion in children with acute respiratory distress syndrome. Annals Of Translational Medicine 2019, 7: 511. PMID: 31728364, PMCID: PMC6828792, DOI: 10.21037/atm.2019.08.28.Peer-Reviewed Original ResearchAcute respiratory distress syndromeRespiratory distress syndromeSevere PARDSDistress syndromeRestrictive red blood cell transfusion strategyRed blood cell transfusion strategyLow oxygen deliveryPossible beneficial effectsProphylactic transfusionStable patientsTransfusion strategyPediatric patientsRBC transfusionHemoglobin levelsLarge trialsAppropriate indicationsPatient populationRecent guidelinesFrequent treatmentTransfusionOxygen deliveryBeneficial effectsHemostatic productsPotential deleterious impactPatientsTransfusion Management in Pediatric Oncology Patients
Nellis ME, Goel R, Karam O. Transfusion Management in Pediatric Oncology Patients. Hematology/Oncology Clinics Of North America 2019, 33: 903-913. PMID: 31466612, DOI: 10.1016/j.hoc.2019.05.011.Peer-Reviewed Original ResearchConceptsPediatric oncology patientsOncology patientsBlood productsStrong evidence-based guidelinesRestrictive transfusion strategyEvidence-based guidelinesNumerous transfusionsPlasma transfusionRed blood cellsTransfusion strategyTransfusion managementPatient populationBlood cellsTransfusionPatientsMorbidity
2016
Massive Transfusion in Children
Karam O, Tucci M. Massive Transfusion in Children. Transfusion Medicine Reviews 2016, 30: 213-216. PMID: 27287298, DOI: 10.1016/j.tmrv.2016.05.010.Peer-Reviewed Original ResearchConceptsMassive transfusionTransfusion protocolTransfusion strategyPacked red blood cellsPediatric trauma patientsGoal-directed therapyWhole bloodMassive transfusion protocolHigh-quality evidenceCritical illnessRed blood cellsTransfusion supportAdjunctive treatmentTrauma patientsQuality evidenceClinical indicatorsTransfusionLaboratory testsBlood componentsBlood cellsFurther studiesAdditional investigationChildrenAdverse consequencesBlood
2015
Indications and Effects of Plasma Transfusions in Critically Ill Children
Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M. Indications and Effects of Plasma Transfusions in Critically Ill Children. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1395-1402. PMID: 25859890, DOI: 10.1164/rccm.201503-0450oc.Peer-Reviewed Original ResearchConceptsInternational normalized ratioMedian international normalized ratioPlasma transfusionIll childrenCoagulation testsBaseline international normalized ratioPediatric intensive care patientsPediatric intensive care unitPartial thromboplastin time valuesCritically Ill ChildrenPoint prevalence studyIntensive care patientsIntensive care unitStrong evidence baseMinor bleedingPostoperative bleedingMost patientsPatient characteristicsTransfusion strategyCare patientsCare unitCritical bleedingNormalized ratioPrimary indicationTransfusion
2013
Plasma transfusion strategies for critically ill patients
Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger PC. Plasma transfusion strategies for critically ill patients. 2013, cd010654. PMID: 24374651, DOI: 10.1002/14651858.cd010654.pub2.Peer-Reviewed Original ResearchConceptsIll patientsPlasma transfusionTransfusion strategyCoagulation testsCochrane Injuries Group's Specialised RegisterInjuries Group Specialised RegisterGroup Specialised RegisterMild coagulation abnormalitiesAbnormal coagulation testsCochrane Central RegisterRisk of bleedingWorse clinical outcomesNon-Indexed CitationsSpecialised RegisterLack of evidenceTransfusion thresholdTrial qualityCentral RegisterCoagulation abnormalitiesCochrane HandbookControlled TrialsReview authorsTrials RegistryClinical effectsClinical outcomes
2011
Red blood cell transfusion thresholds in pediatric patients with sepsis*
Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F. Red blood cell transfusion thresholds in pediatric patients with sepsis*. Pediatric Critical Care Medicine 2011, 12: 512-518. PMID: 21057356, DOI: 10.1097/pcc.0b013e3181fe344b.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionBlood cell transfusionProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeOrgan dysfunction syndromeCell transfusionTransfusion thresholdDysfunction syndromeTransfusion strategySubgroup analysisIll childrenPediatric intensive care unit studyRed blood cell transfusion thresholdRestrictive red-cell transfusion strategyCritical care unit admissionRed-cell transfusion strategyIntensive care unit studiesPediatric critical care unitLiberal transfusion strategyRestrictive transfusion thresholdCare unit admissionSubgroup of patientsCritical care unitsTransfusion requirementsUnit admission