2023
Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis
Aldairi N, Al Ali A, Alabdulqader M, Al Jeraisy M, Cyrus J, Karam O. Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis. Cureus 2023, 15: e39967. PMID: 37416033, PMCID: PMC10320736, DOI: 10.7759/cureus.39967.Peer-Reviewed Original ResearchContinuous renal replacement therapyExtracorporeal membrane oxygenationMolecular adsorbent recirculating systemRenal replacement therapyHypotensive eventsCircuit lifespanReplacement therapyAnticoagulation strategiesMeta-analysisThrombotic eventsExtracorporeal supportSystematic reviewAssociated with fewer bleeding eventsControl seriesProportion of bleedingMortality rateCritically ill childrenCritically ill patientsStatistically significant decreaseMultiple electronic databasesRandomized controlled trialsRisk of biasBleeding eventsMembrane oxygenationSupport modalities
2020
Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis
Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion 2020, 36: 501-512. PMID: 32862767, PMCID: PMC8216320, DOI: 10.1177/0267659120952982.Peer-Reviewed Original ResearchConceptsAnticoagulation strategiesMortality rateThrombotic eventsObservational studySystematic reviewProportion of bleedingType of ECMOExtracorporeal membrane oxygenationMultiple electronic databasesLower mortality rateMembrane oxygenationPatientsElectronic databasesECMOThrombosisSignificant differencesXaBleedingReviewMortalityStudy