2021
Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children
Chegondi M, Vijayakumar N, Billa R, Badheka A, Karam O. Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children. Journal Of Pediatric Intensive Care 2021, 12: 228-234. PMID: 37565022, PMCID: PMC10411082, DOI: 10.1055/s-0041-1731434.Peer-Reviewed Original ResearchPlatelet mass indexPediatric intensive care unitSeptic shockPICU admissionMass indexPrognostic indicatorFl/Day 1Marker of severityRetrospective observational studyIntensive care unitCare unitPediatric sepsisObservational studyClinical valueDay 3SepsisCharacteristic curveFurther studiesAdmissionPMI valuesChildrenAUCSpecificityNonsurvivors
2016
Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Stanworth SJ, Tucci M, Leteurtre S, for the PlasmaTV investigators. Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. Annals Of Intensive Care 2016, 6: 98. PMID: 27714707, PMCID: PMC5053948, DOI: 10.1186/s13613-016-0197-6.Peer-Reviewed Original ResearchPELOD-2 scorePlasma transfusionIll childrenDay 1General pediatric intensive care unit populationPediatric Logistic Organ Dysfunction-2 scorePediatric intensive care unit populationIntensive care unit populationSpecific subpopulationsOrgan dysfunction scoreProspective observational studyHosmer-Lemeshow testObserved mortality ratePELOD-2Dysfunction scoreClinical outcomesOrgan failureResultsFour hundredClinical trialsScore scoresSerial evaluationAncillary studiesObservational studyTransfusionUnit population
2009
Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells
Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion 2009, 49: 2326-2334. PMID: 19624600, DOI: 10.1111/j.1537-2995.2009.02319.x.Peer-Reviewed Original ResearchConceptsWhole blood culturesT cell activationCD25 expressionBlood culturesLeukoreduced RBCsRBC unitsBlood cellsRed blood cell unitsIL-10 levelsTNF-alpha levelsIL-6 levelsTNF-alpha productionTumor necrosis factorWhite blood cellsRed blood cellsIL-10Blood recipientsCytokine productionIL-6Immunomodulatory effectsCytokine releaseNecrosis factorRBC supernatantsDay 1Day 24