2023
Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU
Greenfield K, Karam O, O'Meara A. Stuck in the Dark: No Association between Light, Sound, and Delirium in the PICU. Journal Of Pediatric Intensive Care 2023 DOI: 10.1055/s-0043-1770081.Peer-Reviewed Original ResearchPediatric intensive care unitDevelopment of deliriumAssociated with deliriumCornell Assessment of Pediatric DeliriumPediatric deliriumPediatric intensive care unit patientsIntensive care unitEtiology of deliriumModifiable risk factorsNo significant associationPresence of deliriumTreatment strategiesCare unitIndividual patientsRisk factorsCritical illnessStudy daysPatientsOpiate infusionsSignificant associationCornell AssessmentYounger ageDelirium prevalenceDeliriumNeurological diagnosis
2022
Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB)
Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Network A. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB). Pediatric Critical Care Medicine 2022, 23: 34-51. PMID: 34989711, PMCID: PMC8820267, DOI: 10.1097/pcc.0000000000002851.Peer-Reviewed Original ResearchConceptsIll pediatric patientsPlatelet transfusionsPediatric patientsIll childrenAnemia EXpertise Initiative-Control/AvoidanceSystematic reviewExpert-based consensusMultidisciplinary international expertsPlatelet transfusion practicesGrading of RecommendationsRisk of bleedingAdministration of plasmaConsensus-based statementsCochrane Library databasesEvidence-based recommendationsBest practice statementsClinical decision treeSubject Headings termsCritical illnessIll infantsTransfusion practicePediatric intensivistsConsensus statementTransfusionLibrary databasesCoagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Faustino EVS, Karam O, Parker RI, Hanson SJ, Brandão LR, Monagle P. Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics 2022, 149: s79-s83. PMID: 34970670, DOI: 10.1542/peds.2021-052888l.Peer-Reviewed Original ResearchConceptsCoagulation dysfunctionIll childrenCritical illnessStandard data extraction formOrgan-specific outcomesPediatric critical illnessPODIUM Consensus ConferenceD-dimer valuesInternational normalized ratioPatient-centered outcomesData extraction formOutcomes of interestLiver dysfunctionPlatelet countAdverse outcomesNormalized ratioFunctional statusEligible studiesFibrinogen levelsBias assessmentCoagulation testsCurrent evidenceConsensus conferenceElectronic searchTask force members
2021
Epidemiology of Bleeding in Critically Ill Children
Sequeira J, Nellis ME, Karam O. Epidemiology of Bleeding in Critically Ill Children. Frontiers In Pediatrics 2021, 9: 699991. PMID: 34422724, PMCID: PMC8371326, DOI: 10.3389/fped.2021.699991.Peer-Reviewed Original ResearchPediatric critical care unitRisk of mortalityCritical care unitsIll childrenCare unitClinical outcomesProspective observational cohort studyEpidemiology of BleedingPICU-free daysPercent of patientsVentilator-free daysDuration of surgeryObservational cohort studyCritically Ill ChildrenWorse clinical outcomesType of surgeryFurther multicenter studiesHigher severityCohort studyCritical illnessPediatric IndexSevere complicationsConsecutive patientsIll patientsMedian ageLung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review
Schapka E, Gee J, Cyrus JW, Goldstein G, Greenfield K, Marinello M, Karam O. Lung Ultrasound versus Chest X-Ray for the Detection of Fluid Overload in Critically Ill Children: A Systematic Review. Journal Of Pediatric Intensive Care 2021, 11: 177-182. PMID: 35928036, PMCID: PMC9345674, DOI: 10.1055/s-0041-1725123.Peer-Reviewed Original ResearchChest X-rayFluid overloadLung ultrasoundIll childrenSystematic reviewPerformance of LUSPulmonary fluid overloadPulmonary fluid statusCritically Ill ChildrenQuality of evidenceMultiple electronic databasesCritical illnessCommon complicationVolume overloadClinical burdenFluid statusSensitive modalityEligibility criteriaElectronic databasesFurther evaluationModerate specificityAdult dataGold standardChildrenOverload
2020
How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey.
Demaret P, Karam O, Labreuche Bst J, Chiusolo F, Mayordomo Colunga J, Erickson S, Nellis ME, Perez MH, Ray S, Tucci M, Willems A, Duhamel A, Lebrun F, Loeckx I, Mulder A, Leteurtre S. How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey. Pediatric Critical Care Medicine 2020, 21: e342-e353. PMID: 32217901, DOI: 10.1097/pcc.0000000000002307.Peer-Reviewed Original ResearchConceptsManagement of anemiaPICU dischargePediatric intensivistsTransfusion thresholdCardiac surgeryHemoglobin levelsHemorrhagic shockPrescription of erythropoietinRestrictive transfusion strategyCyanotic heart diseaseCraniofacial surgeryVentricular dysfunctionCritical illnessTransfusion strategyRBC transfusionAcute phaseHeart diseaseSupplemental ironThird of respondentsAnemiaAppropriate managementIntensivistsSurgeryOptimal managementPolytrauma
2019
Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity.
Nellis ME, Tucci M, Lacroix J, Spinella PC, Haque KD, Stock A, Steiner ME, Faustino EVS, Zantek ND, Davis PJ, Stanworth SJ, Cholette JM, Parker RI, Demaret P, Kneyber MCJ, Russell RT, Stricker PA, Vogel AM, Willems A, Josephson CD, Luban NLC, Loftis LL, Leteurtre S, Stocker CF, Goobie SM, Karam O. Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity. Critical Care Medicine 2019, 47: 1766-1772. PMID: 31567407, PMCID: PMC6861687, DOI: 10.1097/ccm.0000000000004025.Peer-Reviewed Original ResearchConceptsIll childrenAssessment ScaleDiagnostic criteriaProspective cohort studyRed cell transfusionCritically Ill ChildrenFuture epidemiologic studiesDelphi consensus processInternational expert consensusRounds of votingBleeding severityRelevant bleedingSubstantial inter-rater reliabilityBleeding episodesCell transfusionCohort studyCritical illnessOrgan dysfunctionOnline Delphi processSurgical interventionPediatric intensivistsPatient outcomesInter-rater reliabilityEpidemiologic studiesExpert consensusAnemia at Discharge From the PICU: A Bicenter Descriptive Study.
Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPICU admissionPICU dischargeRisk of anemiaCritical illnessRisk markersHigher C-reactive protein levelsInotropic/vasopressor supportC-reactive protein levelsWorld Health Organization criteriaMedian hemoglobin levelRetrospective cohort studyElectronic medical recordsVasopressor supportPlasma transfusionCohort studyCreatinine levelsMultivariate adjustmentAnemic childrenHemoglobin levelsMechanical ventilationAnemia statusOrganization criteriaMedical recordsIll childrenCriteria for Clinically Relevant Bleeding in Critically Ill Children
Karam O, Nellis ME, Zantek ND, Lacroix J, Faustino EVS. Criteria for Clinically Relevant Bleeding in Critically Ill Children. Pediatric Critical Care Medicine 2019, Publish Ahead of Print: &na;. PMID: 30575698, DOI: 10.1097/pcc.0000000000001828.Peer-Reviewed Original ResearchConceptsRelevant bleedingStreaks of bloodIll childrenEndotracheal tubeClinical relevancePediatric critical care physiciansClinically Relevant BleedingML/Critical care physiciansCritical illnessIll adultsOrgan failureCare physiciansGastric tubeClinical significanceNurse practitionersBleedingDiagnostic criteriaClinical practiceResponse rateIntensivists' perceptionWeb-based surveyDiagnostic definitionRespondents' geographical locationBlood
2018
Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative
Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: 884-898. PMID: 30180125, PMCID: PMC6126913, DOI: 10.1097/pcc.0000000000001613.Peer-Reviewed Original ResearchConceptsPediatric Critical Care TransfusionAnemia Expertise InitiativeRBC transfusion managementRBC transfusionIll childrenTransfusion managementConsensus recommendationsAnemia Expertise Initiative Consensus ConferenceDevelopment/UCLA Appropriateness MethodExpert consensus-based recommendationsImportant clinical guidanceRBC transfusion practicesAcute brain injuryCongenital heart diseaseConsensus-based recommendationsSearch of PubMedExpert consensus recommendationsUnnecessary RBC transfusionsNonhemorrhagic shockRecommendations AssessmentRespiratory failureCritical illnessHemorrhagic shockTransfusion practiceCochrane LibraryPlatelet Transfusion Practices in Critically Ill Children
Nellis ME, Karam O, Mauer E, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Platelet Transfusion Practices in Critically Ill Children. Critical Care Medicine 2018, 46: 1309-1317. PMID: 29727368, PMCID: PMC6476545, DOI: 10.1097/ccm.0000000000003192.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsCells/LMajor bleedingProphylactic transfusionICU mortalityMinor bleedingIll childrenOverall ICU mortalityPediatric critical illnessPlatelet transfusion practicesProspective cohort studyProphylactic platelet transfusionsCohort studyCritical illnessPost transfusionAdjusted analysisPlatelet countTransfusion practiceAppropriate indicationsMedian changePlatelet doseTransfusionBleedingCells/L.Prophylaxis
2017
Anemia at pediatric intensive care unit discharge: prevalence and risk markers
Demaret P, Karam O, Tucci M, Lacroix J, Behal H, Duhamel A, Lebrun F, Mulder A, Leteurtre S. Anemia at pediatric intensive care unit discharge: prevalence and risk markers. Annals Of Intensive Care 2017, 7: 107. PMID: 29067568, PMCID: PMC5655401, DOI: 10.1186/s13613-017-0328-8.Peer-Reviewed Original ResearchPICU dischargePICU admissionRisk markersOdds ratioPediatric intensive care unit admissionPediatric intensive care unit dischargeIntensive care unit admissionTertiary care children's hospitalIntensive care unit dischargeCare unit admissionNon-cardiac surgeryPrevalence of anemiaProspective observational studyRisk of anemiaConsequences of anemiaMedian Hb levelStrong risk markerUnit admissionAge-based definitionCritical illnessHospital dischargeMultivariate adjustmentAnemic childrenMedical chartsHemoglobin levels
2016
Massive Transfusion in Children
Karam O, Tucci M. Massive Transfusion in Children. Transfusion Medicine Reviews 2016, 30: 213-216. PMID: 27287298, DOI: 10.1016/j.tmrv.2016.05.010.Peer-Reviewed Original ResearchConceptsMassive transfusionTransfusion protocolTransfusion strategyPacked red blood cellsPediatric trauma patientsGoal-directed therapyWhole bloodMassive transfusion protocolHigh-quality evidenceCritical illnessRed blood cellsTransfusion supportAdjunctive treatmentTrauma patientsQuality evidenceClinical indicatorsTransfusionLaboratory testsBlood componentsBlood cellsFurther studiesAdditional investigationChildrenAdverse consequencesBlood