1988
1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia
Petroff O, Young R, Cowan B, Novotny E. 1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia. Pediatric Neurology 1988, 4: 31-34. PMID: 3233106, DOI: 10.1016/0887-8994(88)90021-5.Peer-Reviewed Original ResearchConceptsHigh-energy phosphatesBrain high-energy phosphatesBrain energy stateHypoglycemic brain damageInsulin-induced hypoglycemiaExcitatory amino acidsHypoglycemic brain injuryBrain tissue injuryMagnetic resonance spectroscopy studyAdult experimental animalsBrain glucose contentNeonatal hypoglycemiaExcitatory neurotransmitterInhibitory neurotransmitterMechanisms of resistanceNeonatal dogsBrain damageBrain injuryBrain glutamateTissue injuryEnergy failureNeonatal animalsGABA concentrationExperimental animalsHypoglycemia
1987
In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic state
1983
Cerebral metabolic studies in vivo by 31P NMR.
Prichard J, Alger J, Behar K, Petroff O, Shulman R. Cerebral metabolic studies in vivo by 31P NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 2748-2751. PMID: 6573678, PMCID: PMC393905, DOI: 10.1073/pnas.80.9.2748.Peer-Reviewed Original ResearchConceptsStatus epilepticusCerebral metabolic studiesNitrous oxide analgesiaHypoxic hypoxiaMetabolic disturbancesCardiovascular functionInsulin shockEpilepticusHypoglycemiaLiving rabbitsCreatine kinaseMetabolic stressPhosphocreatine storesHypoxiaMetabolic studiesADP levelsATP levelsReversible decreaseSimilar changesPhosphocreatine poolBrainPhysiological variablesSurface coilAnalgesia