1990
In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy
Petroff O, Novotny E, Ogino T, Avison M, Prichard J. In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy. Journal Of Neurochemistry 1990, 54: 1188-1195. PMID: 2313285, DOI: 10.1111/j.1471-4159.1990.tb01947.x.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopyResonance spectroscopyChemical Shift Selective Magnetic Resonance ImagingVivo 1H magnetic resonance spectroscopyCerebral blood flowBlood ethanol concentrationVivo 1H spectroscopyMagnetic resonance imagingIntragastric administrationBlood flowGas chromatographyRabbit brainResonance imagingSpectroscopyPerchloric acid extractsEthanol levelsAdministrationBrainAcid extractsVivo measurementsCerebralEthanol concentration
1989
Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters
Ment L, Stewart W, Petroff O, Duncan C, Montoya D. Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters. Pediatric Neurology 1989, 5: 281-286. PMID: 2553028, DOI: 10.1016/0887-8994(89)90018-0.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonist MK801Cerebral blood flowBlood flowPerinatal asphyxiaCerebral high-energy phosphatesN-methyl-D-aspartate receptorsSaline 15 minBeagle puppy modelModel of ischemiaNewborn beagle puppiesHigh-energy phosphatesNeuropathologic damageAsphyxial insultPuppy modelNeuronal changesCerebral lactateExcitatory neurotransmitterBrainstem structuresPhosphocreatine levelsDrug treatmentMetabolic insultsBeagle puppiesMK801InsultPuppiesThromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedullaThe Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study
Young R, Chen B, Petroff O, Gore J, Cowan B, Novotny E, Wong M, Zuckerman K. The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study. Pediatric Research 1989, 25: 27-31. PMID: 2919113, DOI: 10.1203/00006450-198901000-00006.Peer-Reviewed Original ResearchConceptsBrain lactateBrain high-energy phosphatesArrest of seizuresFlurothyl-induced seizuresCerebral blood flowNormalization of EEGEffects of diazepamVivo 31P nuclear magnetic resonance spectroscopyHigh-energy phosphatesElectrographic seizuresNeonatal seizuresNeonatal dogsPostictal periodBrain pHBaseline valuesBlood flowBrain phosphocreatineMetabolic recoveryProlonged elevationSeizuresSustained increaseVivo 31PRapid returnDiazepamEnergy phosphates
1987
In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic state