2024
Cobalamin Deficiency in Children with Sickle Cell Disease
Hatabah D, Kreiger R, Brown L, Harris F, Korman R, Benedit L, Rees C, Bakshi N, Dampier C, Morris C. Cobalamin Deficiency in Children with Sickle Cell Disease. 2024, 1 DOI: 10.1093/jscdis/yoae002.011.Peer-Reviewed Original ResearchPrevalence of B12 deficiencyDiagnosis of B12 deficiencyPlasma methylmalonic acidSickle cell diseaseB12 deficiencyMethylmalonic acidCobalamin deficiencyB12 supplementationEffects of B12 supplementationSecondary analysis of samplesTreatment of acute painCell diseaseMarker of B12 deficiencyElevated plasma methylmalonic acidEmergency departmentNon-deficient groupPhase II randomized controlled trialIrreversible neurological impairmentIncreased nutritional requirementsStudent's t-testPediatric emergency departmentRandomized controlled trialsIV opioidsPearson chi-squareRenal impairment
2023
Sex and frequency of pain episodes are associated with acute pain trajectories in adolescents with sickle cell disease
Astles R, Liu Z, Gillespie S, Lai K, Maillis A, Morris C, Lane P, Krishnamurti L, Bakshi N. Sex and frequency of pain episodes are associated with acute pain trajectories in adolescents with sickle cell disease. PAIN Reports 2023, 8: e1084. PMID: 37559677, PMCID: PMC10409410, DOI: 10.1097/pr9.0000000000001084.Peer-Reviewed Original ResearchHigher health care utilizationHealth care utilizationSickle cell diseaseAcute pain trajectoriesPain intensity scoresEmergency departmentPain trajectoriesPain episodesCell diseaseHigher mean pain intensity scoreIntensity scoresMean pain intensity scoreAcute pain episodesFrequency of painAdolescent female patientsFuture prospective studiesElectronic health recordsIntranasal opioidsPain frequencyAcute painPain intensityRetrospective reviewCare utilizationFemale patientsProspective studyIntranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso‐occlusive pain: A multicenter pediatric emergency medicine perspective
Rees C, Brousseau D, Ahmad F, Bennett J, Bhatt S, Bogie A, Brown K, Casper T, Chapman L, Chumpitazi C, Cohen D, Dampier C, Ellison A, Grasemann H, Hatabah D, Hickey R, Hsu L, Bakshi N, Leibovich S, Patil P, Powell E, Richards R, Sarnaik S, Weiner D, Morris C, Group and PECARN T. Intranasal fentanyl and discharge from the emergency department among children with sickle cell disease and vaso‐occlusive pain: A multicenter pediatric emergency medicine perspective. American Journal Of Hematology 2023, 98: 620-627. PMID: 36606705, PMCID: PMC10023395, DOI: 10.1002/ajh.26837.Peer-Reviewed Original ResearchConceptsVaso-occlusive pain episodesSickle cell diseaseIntranasal fentanylEmergency departmentTreatment of childrenMulticenter studyCell diseaseAcademic pediatric emergency departmentOutcome of dischargeVaso-occlusive painAcute care settingPediatric emergency departmentSickling of erythrocytesCross-sectional studyEmergency medicine perspectivePain episodesParenteral analgesicsIntravenous accessMedian ageAdjusted oddsMultivariable associationsFentanylRapid onsetEase of deliveryLogistic regression