Featured Publications
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra NK, Engel J, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P, Consortium F. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke. Epilepsy & Behavior 2021, 127: 108502. PMID: 34968775, DOI: 10.1016/j.yebeh.2021.108502.Peer-Reviewed Original ResearchImpact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review
Misra S, Quinn T, Falcone G, Sharma V, de Havenon A, Zhao Y, Eldem E, French J, Yasuda C, Dawson J, Liebeskind D, Kwan P, Mishra N. Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review. European Journal Of Neurology 2023, 30: 1791-1800. PMID: 36912749, DOI: 10.1111/ene.15777.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyPost-stroke epilepsyTraumatic brain injuryRisk of epilepsySystematic reviewSingle nucleotide polymorphismsBrain injuryOdds ratioRisk of PSERisk of PTEAcute brain injuryGenetic polymorphismsConfidence intervalsAssociation of SNPsQ-Genie toolPSE patientsLate seizuresHazard ratioStroke patientsTBI patientsPrespecified protocolStudy qualityCurrent evidenceEpilepsyPatientsOutcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testClinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR)
Mishra N, Kwan P, Tanaka T, Sunnerhagen K, Dawson J, Zhao Y, Misra S, Wang S, Sharma V, Mazumder R, Funaro M, Ihara M, Nicolo J, Liebeskind D, Yasuda C, Cendes F, Quinn T, Ge Z, Scalzo F, Zelano J, Kasner S, Consortium I, Mishra N, Kwan P, Friedman A, Engel J. Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR). BMJ Open 2023, 13: e078684. PMID: 37968000, PMCID: PMC10660442, DOI: 10.1136/bmjopen-2023-078684.Peer-Reviewed Original ResearchConceptsPost-stroke epilepsyPost-stroke seizuresIndividual patient dataClinical characteristicsLate post-stroke seizuresPatient dataOutcomes of patientsFuture clinical trialsPatient outcome measuresComprehensive search strategyAcute strokePeer-reviewed journalsStroke patientsPrognostic valueStroke mortalityBias assessmentClinical trialsObservational studyOutcome measuresLanguage of publicationEpileptic seizuresPatientsEthics approvalStudy authorsIPD-MAComparison of Sex-Based In-Hospital Procedural Outcomes and Hospital Readmission Frequency After Patent Foramen Ovale Occluder Device Placement: A Propensity Matched National Cohort
Fakhra S, Sattar Y, Patel N, Aziz S, Titus A, Almas T, Aamir M, Sulaiman S, Mishra N, Elgendy I, Raina S, Jagadeesan V, Daggubati R, Alraies M. Comparison of Sex-Based In-Hospital Procedural Outcomes and Hospital Readmission Frequency After Patent Foramen Ovale Occluder Device Placement: A Propensity Matched National Cohort. Current Problems In Cardiology 2023, 48: 101662. PMID: 36868331, DOI: 10.1016/j.cpcardiol.2023.101662.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAcute ischemic strokeNationwide Readmissions DatabaseMultivariate odds ratiosDevice placementAKI incidenceHospital mortalityCardiac tamponadeIschemic strokeHigher total hospitalization costsNational retrospective cohort studySecondary cardiovascular outcomesRetrospective cohort studyTotal hospitalization costsComparison of sexAKI occurrenceNephrotoxic medicationsReadmission LOSRecurrent strokeCardiovascular outcomesIndex hospitalizationKidney injuryPostprocedural bleedingCohort studyComplication ratePathophysiology, Diagnosis, Prognosis, and Prevention of Poststroke Epilepsy
Tanaka T, Ihara M, Fukuma K, Mishra N, Koepp M, Guekht A, Ikeda A. Pathophysiology, Diagnosis, Prognosis, and Prevention of Poststroke Epilepsy. Neurology 2024, 102: e209450. PMID: 38759128, PMCID: PMC11175639, DOI: 10.1212/wnl.0000000000209450.Peer-Reviewed Original ResearchConceptsPoststroke epileptogenesisPoststroke epilepsyStroke survivorsAssociated with high mortalityAttention of health policymakersBurden of stroke worldwideDiagnostic work-upRisk of seizuresRisk-scoring modelSurrogate outcome measuresCortical superficial siderosisPrevention of seizuresSecondary prevention of seizuresPrimary prophylaxisConcomitant medicationsEEG findingsAcute stroke treatmentRecurrence riskSeizure prophylaxisSuperficial siderosisAntiseizure medicationsCardiovascular riskTreatment strategiesEnrolling patientsTissue-based approach
2018
Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke
Tsai JP, Mlynash M, Christensen S, Kemp S, Kim S, Mishra NK, Federau C, Nogueira RG, Jovin TG, Devlin TG, Akhtar N, Yavagal DR, Bammer R, Straka M, Zaharchuk G, Marks MP, Albers GW, Lansberg MG. Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke. Stroke 2018, 49: 952-957. PMID: 29581341, PMCID: PMC5875452, DOI: 10.1161/strokeaha.117.018858.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAngiography, Digital SubtractionCerebral AngiographyCohort StudiesEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedPerfusion ImagingPrognosisRecovery of FunctionReperfusionStrokeThrombectomyTime-to-TreatmentTomography, X-Ray ComputedTreatment OutcomeConceptsTarget mismatch profileReperfusion timeFunctional independenceMismatch profileInfarct growthCTP scansLarger final infarct volumeTarget mismatch patientsAcute ischemic strokeCohort of patientsFinal infarct volumeTarget mismatchSuccessful endovascular reperfusionMismatch patientsEndovascular reperfusionInfarct volumeRadiological outcomesSuccessful reperfusionAcute strokeIschemic strokeRadiographic outcomesEndovascular therapyBaseline imagingMalignant profileTomographic perfusion
2017
Computed tomographic perfusion to Predict Response to Recanalization in ischemic stroke
Lansberg MG, Christensen S, Kemp S, Mlynash M, Mishra N, Federau C, Tsai JP, Kim S, Nogueria RG, Jovin T, Devlin TG, Akhtar N, Yavagal DR, Haussen D, Dehkharghani S, Bammer R, Straka M, Zaharchuk G, Marks MP, Albers GW, Investigators F. Computed tomographic perfusion to Predict Response to Recanalization in ischemic stroke. Annals Of Neurology 2017, 81: 849-856. PMID: 28486789, PMCID: PMC5521988, DOI: 10.1002/ana.24953.Peer-Reviewed Original ResearchConceptsBaseline CT perfusionSymptom onsetEndovascular therapyCT perfusionTomographic perfusionConsecutive acute stroke patientsSmall ischemic coreTarget mismatch profileMulticenter cohort studyAcute stroke patientsFavorable clinical responseSelection of patientsTarget mismatchRate of reperfusionCT perfusion studyMagnetic resonance imagingAnn NeurolCritical hypoperfusionEndovascular reperfusionClinical responseCohort studyIschemic strokeIschemic coreStroke patientsPatient population
2016
Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes
Kasasbeh AS, Christensen S, Straka M, Mishra N, Mlynash M, Bammer R, Albers GW, Lansberg MG. Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes. Stroke 2016, 47: 2966-2971. PMID: 27895299, PMCID: PMC5134896, DOI: 10.1161/strokeaha.116.014177.Peer-Reviewed Original ResearchConceptsVenous output functionOptimal scan timeLesion volumePerfusion scanAcute stroke patientsIschemic lesion volumeStroke lesion volumeScan durationLesion volume measurementsMost patientsStroke patientsTomographic perfusionOptimal durationScan protocolTotal scan durationContrast bolusScansScan timePatientsSufficient durationDurationVolume measurementsShort scan durationPerfusionBolusComparison of stroke volume evolution on diffusion-weighted imaging and fluid-attenuated inversion recovery following endovascular thrombectomy
Federau C, Christensen S, Mlynash M, Tsai J, Kim S, Zaharchuk G, Inoue M, Straka M, Mishra NK, Kemp S, Lansberg MG, Albers GW. Comparison of stroke volume evolution on diffusion-weighted imaging and fluid-attenuated inversion recovery following endovascular thrombectomy. International Journal Of Stroke 2016, 12: 510-518. PMID: 27811306, DOI: 10.1177/1747493016677985.Peer-Reviewed Original ResearchConceptsInfarct lesion volumeFluid-attenuated inversion recoveryDiffusion-weighted imagingLesion volumeEndovascular thrombectomyInversion recoveryDay 5Fluid-attenuated inversion recovery lesionsPost-stroke onsetDegree of reperfusionStroke lesion volumeFluid-attenuated inversion recovery imagesInversion recovery imagesInfarct volumeInfarct growthStroke onsetSymptom onsetLesion growthPatientsRecovery imagesInterquartile rangeThrombectomyProcedure imagesA benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard
Cereda CW, Christensen S, Campbell B, Mishra NK, Mlynash M, Levi C, Straka M, Wintermark M, Bammer R, Albers GW, Parsons MW, Lansberg MG. A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard. Cerebrovascular And Brain Metabolism Reviews 2016, 36: 1780-1789. PMID: 26661203, PMCID: PMC5076783, DOI: 10.1177/0271678x15610586.Peer-Reviewed Original ResearchBlood Pressure Management in Acute Stroke.
Jusufovic M, Mishra NK, Lansberg MG, Bath PM, Berge E, Sandset EC. Blood Pressure Management in Acute Stroke. Current Hypertension Reviews 2016, 12: 121-6. PMID: 26931471, DOI: 10.2174/1573402112666160302102711.Peer-Reviewed Original ResearchConceptsBlood pressure managementAcute ischemic strokeBlood pressureIschemic strokeIntracerebral hemorrhageAcute phaseClinical trialsPressure managementAcute stroke treatmentIndependent risk factorLower blood pressureLarge clinical trialsRecent clinical trialsRoutine clinical practicePenumbral tissueAcute strokeThrombolytic treatmentStroke treatmentClinical benefitUnfavourable outcomeRisk factorsClinical practiceHemorrhageInternational guidelinesStroke
2015
Test Accuracy of Informant-Based Cognitive Screening Tests for Diagnosis of Dementia and Multidomain Cognitive Impairment in Stroke
McGovern A, Pendlebury ST, Mishra NK, Fan Y, Quinn TJ. Test Accuracy of Informant-Based Cognitive Screening Tests for Diagnosis of Dementia and Multidomain Cognitive Impairment in Stroke. Stroke 2015, 47: 329-335. PMID: 26683423, DOI: 10.1161/strokeaha.115.011218.Peer-Reviewed Original ResearchResponse to endovascular reperfusion is not time-dependent in patients with salvageable tissue
Lansberg MG, Cereda CW, Mlynash M, Mishra NK, Inoue M, Kemp S, Christensen S, Straka M, Zaharchuk G, Marks MP, Bammer R, Albers GW, Saver J, Fayad P, Howard G, Tomsick. T, Jovin T, Wechsler L, DeCesare S, Thai D, Sherr A, Wilder M, Tricot A, Lutsep H, McDaneld L, Larsen D, Czartoski T, Keogh B, Malik A, Brown A, Bernstein R, Muskovich K, Chang C, Stern T, Warach S, Davis L, Fazekas F, Seifert-Held T. Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue. Neurology 2015, 85: 708-714. PMID: 26224727, PMCID: PMC4553034, DOI: 10.1212/wnl.0000000000001853.Peer-Reviewed Original ResearchConceptsGood functional outcomeEndovascular reperfusionFunctional outcomeSalvageable tissueLesion volumeLesion growthRandomized placebo-controlled trialModified Rankin Scale scorePerfusion Imaging EvaluationPerfusion lesion volumeTarget mismatch profilePlacebo-controlled trialRankin Scale scorePerfusion-diffusion mismatchSubgroup of patientsRadiologic outcomesCohort studyEndovascular therapyEarly followStroke patientsImaging evaluationReperfusionDay 90PatientsScale scoreReperfusion of Very Low Cerebral Blood Volume Lesion Predicts Parenchymal Hematoma After Endovascular Therapy
Mishra NK, Christensen S, Wouters A, Campbell BC, Straka M, Mlynash M, Kemp S, Cereda CW, Bammer R, Marks MP, Albers GW, Lansberg MG. Reperfusion of Very Low Cerebral Blood Volume Lesion Predicts Parenchymal Hematoma After Endovascular Therapy. Stroke 2015, 46: 1245-1249. PMID: 25828235, PMCID: PMC4414872, DOI: 10.1161/strokeaha.114.008171.Peer-Reviewed Original ResearchConceptsParenchymal hemorrhageIntravenous alteplaseEndovascular therapyBaseline imagingLesion volumeLow cerebral blood volumePerfusion Imaging EvaluationIschemic stroke patientsEndovascular reperfusion therapySingle independent predictorRoutine clinical practiceCerebral blood volumeMagnetic resonance imagingRegional reperfusionParenchymal hematomaReperfusion therapyIndependent predictorsEarly followRisk stratificationStroke patientsImaging evaluationNormal perfusionVLCBVBlood volumePatients
2014
Comparison of Magnetic Resonance Imaging Mismatch Criteria to Select Patients for Endovascular Stroke Therapy
Mishra NK, Albers GW, Christensen S, Marks M, Hamilton S, Straka M, Liggins JT, Kemp S, Mlynash M, Bammer R, Lansberg MG. Comparison of Magnetic Resonance Imaging Mismatch Criteria to Select Patients for Endovascular Stroke Therapy. Stroke 2014, 45: 1369-1374. PMID: 24699054, PMCID: PMC4007191, DOI: 10.1161/strokeaha.114.004772.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarotid Artery DiseasesCerebrovascular DisordersDiffusion Magnetic Resonance ImagingFemaleHumansInfarction, Middle Cerebral ArteryMagnetic Resonance AngiographyMaleMiddle AgedMultimodal ImagingPerfusion ImagingReperfusionSeverity of Illness IndexStrokeTreatment OutcomeConceptsFavorable clinical responseMRA-DWI mismatchClinical responseMagnetic resonance angiographyDay 30Endovascular stroke trialsPerfusion Imaging EvaluationHealth Stroke ScaleGood functional outcomeEndovascular stroke therapyPerfusion-diffusion mismatchPWI-DWI mismatchInternal carotid arteryDEFUSE 2Endovascular reperfusionM1 occlusionMismatch criteriaNIHSS scoreStroke ScalePatient selectionStroke therapyStroke trialsFunctional outcomeImaging evaluationVessel occlusion
2013
J. T. P. Liggins et al.
Liggins JT, Yoo AJ, Mishra NK, Wheeler HM, Straka M, Leslie‐Mazwi T, Chaudhry ZA, Kemp S, Mlynash M, Bammer R, Albers GW, Lansberg MG, Investigators D. J. T. P. Liggins et al. International Journal Of Stroke 2013, 10: 705-709. PMID: 24207136, PMCID: PMC4048330, DOI: 10.1111/ijs.12207.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingBrain IschemiaCohort StudiesDatabases, FactualDiffusion Magnetic Resonance ImagingFemaleFibrinolytic AgentsHumansLogistic ModelsMaleMiddle AgedMulticenter Studies as TopicOutcome Assessment, Health CareSeverity of Illness IndexStrokeTissue Plasminogen ActivatorTreatment OutcomeConceptsPoor functional outcomeDiffusion-weighted imaging scoreFunctional outcomeImaging scoresTherapy scoreClinical responseDiffusion-weighted imaging volumeModified Rankin Scale scoreAcute stroke interventionAcute ischemic strokePercentage of patientsPredictive scoring systemRankin Scale scorePredictors of outcomeCharacteristic curveDiffusion-Weighted ImagingIschemic strokeEndovascular therapyIndependent predictorsPatient ageStroke interventionEndovascular treatmentValidation cohortClinical variablesLesion volumeInfluence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke
Mishra NK, Mandava P, Chen C, Grotta J, Lees KR, Kent TA, collaboration V. Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke. International Journal Of Stroke 2013, 9: 613-617. PMID: 24148895, DOI: 10.1111/ijs.12162.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorBaseline National InstitutesHealth Stroke ScaleNon-Caucasian patientsPlasminogen activatorStroke ScaleNational InstituteRace-EthnicityNon-thrombolysed patientsStroke III TrialRace-ethnicity groupsNeuroprotection trialsIII trialsDiabetes statusFunctional outcomeImproved outcomesPatientsNeurological disordersCaucasian populationDifferential responseEthnicity groupsOutcomesCaucasiansOddsTrialsPostthrombolysis outcomes in acute ischemic stroke patients of Asian race‐ethnicity
Mishra NK, Chan BP, Teoh H, Meng C, Lees KR, Chen C, Sharma VK, collaboration F. Postthrombolysis outcomes in acute ischemic stroke patients of Asian race‐ethnicity. International Journal Of Stroke 2013, 8: 95-99. PMID: 23490069, DOI: 10.1111/ijs.12012.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchiveThrombolytic therapyStroke patientsAsian patientsHealth Stroke Scale scorePropensity score-matched patientsAcute ischemic stroke patientsTissue plasminogen activator therapyAsian stroke patientsBaseline National InstitutesPropensity-matched cohortStroke Scale scoreIschemic stroke patientsProportional odds logistic regression analysisPlasminogen activator therapyNational University HospitalLogistic regression analysisNational InstituteRace-ethnic differencesNeurological outcomeRankin scoreThrombolyzed patientsPropensity matchingTertiary centerActivator therapyThrombolysis in Stroke Despite Contraindications or Warnings?
Frank B, Grotta JC, Alexandrov AV, Bluhmki E, Lyden P, Meretoja A, Mishra NK, Shuaib A, Wahlgren NG, Weimar C, Lees KR. Thrombolysis in Stroke Despite Contraindications or Warnings? Stroke 2013, 44: 727-733. PMID: 23391774, DOI: 10.1161/strokeaha.112.674622.Peer-Reviewed Original ResearchConceptsHealth Stroke ScoreAlteplase treatmentStroke ScoreOdds ratioBaseline National InstitutesIntravenous alteplase treatmentPretreatment National InstitutesSingle antiplatelet agentTrial selection criteriaAcute ischemic strokeIschemic stroke patientsProportional odds logistic regression analysisSubgroup of patientsAdjusted odds ratioCommon clinical situationsNational InstituteLogistic regression analysisInternational normalizedIntravenous thrombolysisOral anticoagulationPrior strokeComprehensive retrospective analysisIschemic strokeRankin ScaleUntreated patients