Homogeneous organic reductant based on 4,4′- t Bu2-2,2′-bipyridine for cross-electrophile coupling
Charboneau D, Huang H, Barth E, Deziel A, Germe C, Hazari N, Jia X, Kim S, Nahiyan S, Birriel–Rodriguez L, Uehling M. Homogeneous organic reductant based on 4,4′- t Bu2-2,2′-bipyridine for cross-electrophile coupling. Tetrahedron Letters 2024, 145: 155159. PMID: 39036418, PMCID: PMC11258959, DOI: 10.1016/j.tetlet.2024.155159.Peer-Reviewed Original ResearchCross-electrophile coupling reactionsHomogeneous reductionCross-electrophile couplingHomogeneous organic reductantsC(sp2)–C(sp3Organic transformationsCoupling reactionMultigram scaleOrganic solventsReduction potentialFunctional groupsOrganic reductantsBu2Ferrocenium/ferroceneMultigramSolventNi/CoReactionSynthesisEffect of 6,6′-Substituents on Bipyridine-Ligated Ni Catalysts for Cross-Electrophile Coupling
Huang H, Alvarez-Hernandez J, Hazari N, Mercado B, Uehling M. Effect of 6,6′-Substituents on Bipyridine-Ligated Ni Catalysts for Cross-Electrophile Coupling. ACS Catalysis 2024, 14: 6897-6914. PMID: 38737398, PMCID: PMC11087080, DOI: 10.1021/acscatal.4c00827.Peer-Reviewed Original ResearchBulky substituentsNi complexesCross-electrophile couplingNi-catalyzed transformationII oxidation stateActive catalystTurnover frequencyCatalytic performanceAlkyl radicalsCatalytic intermediatesNi catalystsSubstituentsLow-spinCatalytic activityOxidation stateCl speciesHigh-spinCatalystLigandRoom temperatureBu2ReactionComplexPrecatalystXeC