Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
Park TS, Zimmerlin L, Evans-Moses R, Thomas J, Huo JS, Kanherkar R, He A, Ruzgar N, Grebe R, Bhutto I, Barbato M, Koldobskiy MA, Lutty G, Zambidis ET. Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina. Nature Communications 2020, 11: 1195. PMID: 32139672, PMCID: PMC7058090, DOI: 10.1038/s41467-020-14764-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBlood VesselsCell DifferentiationCell LineCell LineageCell MovementCellular SenescenceDiabetes MellitusDNA DamageEnzyme InhibitorsEpigenesis, GeneticFibroblastsHistone CodeHumansInduced Pluripotent Stem CellsIschemiaMiceOrganoidsPoly(ADP-ribose) Polymerase InhibitorsPromoter Regions, GeneticRetinaStem CellsTankyrasesTeratomaTranscription, GeneticConceptsVascular progenitorsLineage-primed gene expressionPluripotent stem cell stateGreater genomic stabilityStem cell stateStem cellsPluripotent stem cellsPatient-specific hiPSCsEpigenetic plasticityHuman stem cellsPluripotent stateGenomic stabilityCell statesGene expressionHuman iPSCProgenitorsHiPSCsRegenerative medicineEfficient revascularizationCellsConventional humanVascular functionalityIPSCsPlasticity