2021
Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma
Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.Peer-Reviewed Original ResearchDNA methylationGene expressionSubtype-specific gene expressionDifferential DNA methylationGene expression patternsPromoter CpG islandsRNA-seq dataEpigenetic regulationEpigenetic profilingEpigenetic signaturesCpG islandsEpigenetic alterationsExpression patternsGenesMethylationUnsupervised hierarchical clusteringPotential therapeutic targetMolecular landscapeIntegrated analysisMain clustersPotential targetTherapeutic targetExpressionSubtype-specific differencesMultiple aspects
2020
Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina
Park TS, Zimmerlin L, Evans-Moses R, Thomas J, Huo JS, Kanherkar R, He A, Ruzgar N, Grebe R, Bhutto I, Barbato M, Koldobskiy MA, Lutty G, Zambidis ET. Vascular progenitors generated from tankyrase inhibitor-regulated naïve diabetic human iPSC potentiate efficient revascularization of ischemic retina. Nature Communications 2020, 11: 1195. PMID: 32139672, PMCID: PMC7058090, DOI: 10.1038/s41467-020-14764-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBlood VesselsCell DifferentiationCell LineCell LineageCell MovementCellular SenescenceDiabetes MellitusDNA DamageEnzyme InhibitorsEpigenesis, GeneticFibroblastsHistone CodeHumansInduced Pluripotent Stem CellsIschemiaMiceOrganoidsPoly(ADP-ribose) Polymerase InhibitorsPromoter Regions, GeneticRetinaStem CellsTankyrasesTeratomaTranscription, GeneticConceptsVascular progenitorsLineage-primed gene expressionPluripotent stem cell stateGreater genomic stabilityStem cell stateStem cellsPluripotent stem cellsPatient-specific hiPSCsEpigenetic plasticityHuman stem cellsPluripotent stateGenomic stabilityCell statesGene expressionHuman iPSCProgenitorsHiPSCsRegenerative medicineEfficient revascularizationCellsConventional humanVascular functionalityIPSCsPlasticity