Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy
Bachtel ND, Beckerle GA, Mota TM, de Mulder Rougvie M, Raposo RAS, Jones RB, Nixon DF, Apps R. Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy. AIDS Research And Human Retroviruses 2018, 35: 108-111. PMID: 30198299, PMCID: PMC6343196, DOI: 10.1089/aid.2018.0162.Peer-Reviewed Original ResearchConceptsHIV-1-infected individualsHost restriction factorsRestriction factor expressionEffective antiretroviral therapyAntiretroviral therapyUninfected individualsMemory CD4Viral reservoirRestriction factorsT cellsChronic HIV-1 infectionHIV-1 gag DNAHIV-1 reservoir sizeFactor expressionMemory T cell compartmentQuantitative viral outgrowth assaysART-suppressed individualsSuppressive antiretroviral therapyViral outgrowth assaysHIV-1 infectionT cell compartmentDroplet digital polymerase chain reactionGag DNAViral loadImmune activationHLA-C downregulation by HIV-1 adapts to host HLA genotype
Bachtel ND, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete GQ, Chatterjee P, Lee GQ, Thomas R, Brockman MA, Neil S, Carrington M, Bwana B, Bangsberg DR, Martin JN, Kallas EG, Donini C, Cerqueira NB, O’Doherty U, Hahn BH, Jones RB, Brumme ZL, Nixon DF, Apps R. HLA-C downregulation by HIV-1 adapts to host HLA genotype. PLOS Pathogens 2018, 14: e1007257. PMID: 30180214, PMCID: PMC6138419, DOI: 10.1371/journal.ppat.1007257.Peer-Reviewed Original ResearchConceptsViral downregulationHLA-C allelesHLA-C expressionChronic infectionHLA genotypeHIV-1Primary HIV-1 variantsPrimary HIV-1 virusesEffective anti-retroviral therapyAnti-retroviral therapyTreatment-naïve individualsDownregulation of HLAMonths of infectionHIV-1 variantsViral immune evasionHIV-1 virusSurface HLACTL responsesUntreated infectionViral protein VpuImmune evasionHLAInfectionInfected cellsDownregulation