2000
Synergistic Effect of Adrenal Steroids and Angiotensin II on Plasminogen Activator Inhibitor-1 Production1
Brown N, Kim K, Chen Y, Blevins L, Nadeau J, Meranze S, Vaughan D. Synergistic Effect of Adrenal Steroids and Angiotensin II on Plasminogen Activator Inhibitor-1 Production1. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 336-344. PMID: 10634408, DOI: 10.1210/jcem.85.1.6305.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAdrenal GlandsAldosteroneAngiotensin IIAnimalsBlotting, NorthernCells, CulturedChromosome MappingDexamethasoneGenes, ReporterHumansHydrocortisoneHyperaldosteronismMuscle, Smooth, VascularMutagenesis, Site-DirectedPlasminogen Activator Inhibitor 1RatsTissue Plasminogen ActivatorTransfectionConceptsPAI-1 expressionAng IIEffects of aldosteroneAngiotensin IIVenous bloodTissue plasminogen activator antigenPAI-1 antigen concentrationsSelective adrenal veinHuman PAI-1 promoterL Ang IIPeripheral venous bloodRat aortic smooth muscle cellsAdrenal venous bloodPlasminogen activator antigenAortic smooth muscle cellsPlasminogen activator inhibitor-1 productionCultured human umbilical vein endothelial cellsPlasminogen activator inhibitor expressionPAI-1 antigenSmooth muscle cellsHuman umbilical vein endothelial cellsDose-dependent mannerUmbilical vein endothelial cellsL aldosteroneAdrenal veinSynergistic Effect of Adrenal Steroids and Angiotensin II on Plasminogen Activator Inhibitor-1 Production
Brown NJ. Synergistic Effect of Adrenal Steroids and Angiotensin II on Plasminogen Activator Inhibitor-1 Production. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 336-344. DOI: 10.1210/jc.85.1.336.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAdrenal GlandsAldosteroneAngiotensin IIAnimalsBlotting, NorthernCells, CulturedChromosome MappingDexamethasoneGenes, ReporterHumansHydrocortisoneHyperaldosteronismMuscle, Smooth, VascularMutagenesis, Site-DirectedPlasminogen Activator Inhibitor 1RatsTissue Plasminogen ActivatorTransfection
1993
Caffeine attenuates the renal vascular response to angiotensin II infusion.
Brown NJ, Ryder D, Nadeau J. Caffeine attenuates the renal vascular response to angiotensin II infusion. Hypertension 1993, 22: 847-852. PMID: 8244516, DOI: 10.1161/01.hyp.22.6.847.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAldosteroneAnalysis of VarianceAngiotensin IIBlood PressureCaffeineCreatinineDose-Response Relationship, DrugDrug AntagonismHumansInfusions, IntravenousMetabolic Clearance RateP-Aminohippuric AcidPotassiumRenal CirculationReninSingle-Blind MethodSodiumSodium Chloride, DietaryConceptsRenal plasma flowRenal plasma flow responsePara-aminohippurate clearancePlasma renin activityAngiotensin II infusionAng IIII infusionPlasma flow responseRenin activityBlood pressureEndogenous adenosineShort-term angiotensin II infusionBaseline plasma renin activityBaseline renal plasma flowTissue Ang II levelsAdenosine receptor antagonist caffeineRenal vascular responseRenal vasoconstrictive responseAng II levelsAng II infusionBaseline blood pressureBlood pressure responsePlacebo-controlled studyLong-term administrationTissue adenosine levels