1997
Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant
Gainer J, Hunley T, Kon V, Nadeau J, Muldowney J, Brown N. Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant. IUBMB Life 1997, 43: 227-231. PMID: 9315301, DOI: 10.1080/15216549700204001.Peer-Reviewed Original ResearchConceptsC1166 variantAngiotensin II type I receptorAfrican AmericansNormotensive African AmericansType I receptorReceptor polymorphismsAfrican American populationCaucasian subjectsI receptorSubstitution polymorphismCaucasiansAmerican populationHypertensionLow frequencyPolymorphismAmericansVariantsReceptors
1996
Increased sensitivity to bradykinin among African Americans
Gainer J, Nadeau J, Ryder D, Brown N. Increased sensitivity to bradykinin among African Americans. Journal Of Allergy And Clinical Immunology 1996, 98: 283-287. PMID: 8757204, DOI: 10.1016/s0091-6749(96)70151-3.Peer-Reviewed Original ResearchConceptsKallikrein-kinin systemWheal responseAfrican AmericansLife-threatening side effectsTissue kallikrein-kinin systemACE inhibitor-associated angioedemaACE inhibitor doseMechanisms of angioedemaDouble-blind fashionDoses of bradykininAfrican American raceNormotensive African AmericansUrinary kallikrein levelsACE inhibitor-induced increaseInhibitor-induced increaseBradykinin doseConcurrent medicationsEssential hypertensionKallikrein levelsBradykinin levelsExogenous bradykininIntradermal injectionAmerican raceSide effectsInhibitor dose