2010
Increased Sensitivity to Angiotensin II Is Present Postpartum in Women With a History of Hypertensive Pregnancy
Saxena AR, Karumanchi SA, Brown NJ, Royle CM, McElrath TF, Seely EW. Increased Sensitivity to Angiotensin II Is Present Postpartum in Women With a History of Hypertensive Pregnancy. Hypertension 2010, 55: 1239-1245. PMID: 20308605, PMCID: PMC2880505, DOI: 10.1161/hypertensionaha.109.147595.Peer-Reviewed Original ResearchConceptsLow-sodium balanceSoluble fms-like tyrosine kinase-1 levelsHypertensive pregnanciesDiastolic blood pressureAngiotensin IIBlood pressurePressor responseHigh sodium balanceInfused angiotensin IISystolic pressor responseNew-onset hypertensionAngiotensin II infusionFuture cardiovascular riskHigh-salt dietSystolic blood pressureII infusionCardiovascular riskNormotensive pregnanciesPostpartum womenSodium balancePregnancySalt loadingPostpartumDietary phasesWomen
2004
Uric acid and the state of the intrarenal renin-angiotensin system in humans
Perlstein TS, Gumieniak O, Hopkins PN, Murphey LJ, Brown NJ, Williams GH, Hollenberg NK, Fisher ND. Uric acid and the state of the intrarenal renin-angiotensin system in humans. Kidney International 2004, 66: 1465-1470. PMID: 15458439, DOI: 10.1111/j.1523-1755.2004.00909.x.Peer-Reviewed Original ResearchConceptsIntrarenal renin-angiotensin systemRenin-angiotensin systemSerum uric acid concentrationBody mass indexHigh-density lipoproteinUric acid concentrationRenal vascular responsePlasma renin activityAng IIRPF responseExperimental hyperuricemiaBlood pressureVascular responsesUric acidRenal plasma flow responsePara-aminohippuric acid clearanceHigh sodium balanceIntrarenal RAS activityRenal vascular responsivenessExogenous angiotensin IISerum high-density lipoproteinSerum uric acidMultivariable regression analysisPlasma flow responseRenin activity