2012
Obesity and Oxidative Stress Predict AKI after Cardiac Surgery
Billings FT, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, Brown NJ. Obesity and Oxidative Stress Predict AKI after Cardiac Surgery. Journal Of The American Society Of Nephrology 2012, 23: 1221-1228. PMID: 22626819, PMCID: PMC3380645, DOI: 10.1681/asn.2011090940.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAngiotensin-Converting Enzyme InhibitorsBiomarkersBody Mass IndexCardiac Surgical ProceduresDiureticsF2-IsoprostanesFemaleHumansInterleukin-6MaleMiddle AgedObesityOxidative StressPlasminogen Activator Inhibitor 1Postoperative ComplicationsRamiprilRandomized Controlled Trials as TopicRisk FactorsSignal TransductionSpironolactone
2004
Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension
Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O’Donnell C, Brown NJ, Waterman MR, Capdevila JH. Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension. Circulation 2004, 111: 63-69. PMID: 15611369, DOI: 10.1161/01.cir.0000151309.82473.59.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesAmino Acid SubstitutionArachidonic AcidBlack PeopleBlood PressureCodonCohort StudiesComorbidityCytochrome P-450 CYP4ACytochrome P-450 Enzyme SystemDNA Mutational AnalysisFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansHydroxyeicosatetraenoic AcidsHypertensionIntronsKidneyLauric AcidsMaleMiddle AgedMultifactorial InheritanceMutagenesis, InsertionalMutation, MissensePoint MutationSequence DeletionTennesseeUnited StatesWhite PeopleConceptsArachidonic acidORs of hypertensionBlood pressure controlBody mass indexEndogenous arachidonic acidLarge population databaseFramingham Heart StudySevere hypertensionEssential hypertensionHypertension comorbidityTubular functionHypertensive statusMass indexFunctional variantsHypertensionHeart StudyPressure controlCYP4A11Polygenic determinantsPopulation databaseTargeted disruptionHuman CYP4A11Acid synthaseAssociationSynthase activity