1998
ACE Insertion/Deletion Genotype Affects Bradykinin Metabolism
Brown N, Blais C, Gandhi S, Adam A. ACE Insertion/Deletion Genotype Affects Bradykinin Metabolism. Journal Of Cardiovascular Pharmacology 1998, 32: 373-377. PMID: 9733349, DOI: 10.1097/00005344-199809000-00006.Peer-Reviewed Original ResearchConceptsSerum ACE activityAng IIACE activityPlasma Ang II concentrationACE insertion/deletion genotypeACE deletion alleleAng I infusionAng II concentrationsDeleterious cardiovascular effectsACE D alleleInsertion/deletion genotypeSignificant inverse relationACE deletionCardiovascular morbidityCardiovascular effectsI infusionAng IACE genotypeACE levelsACE DDBradykinin degradationAngiotensin ID alleleSynthetic bradykininDeletion allele
1996
The Renin-Angiotensin and Fibrinolytic Systems Co-Conspirators in the Pathogenesis of Ischemic Cardiovascular Disease
Brown N, Vaughan D. The Renin-Angiotensin and Fibrinolytic Systems Co-Conspirators in the Pathogenesis of Ischemic Cardiovascular Disease. Trends In Cardiovascular Medicine 1996, 6: 239-243. PMID: 21232303, DOI: 10.1016/s1050-1738(96)00091-6.Peer-Reviewed Original ResearchTissue-type plasminogen activatorFibrinolytic systemIschemic cardiovascular eventsRenin-angiotensin systemBreakdown of bradykininCardiovascular eventsAngiotensin IIT-PA secretionClinical observationsPotent stimulusStimulates releaseAngiotensin IPAI-1Plasminogen activatorVivo dataMajor inhibitorACEAngiotensinBradykininSecretionVasculature