2023
Underlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials
Zilcha-Mano S, Duek O, Suarez-Jimenez B, Zhu X, Lazarov A, Helpman L, Korem N, Malka M, Harpaz-Rotem I, Neria Y. Underlying Hippocampal Mechanism of Posttraumatic Stress Disorder Treatment Outcome: Evidence From Two Clinical Trials. Biological Psychiatry Global Open Science 2023, 3: 867-874. PMID: 37881552, PMCID: PMC10593870, DOI: 10.1016/j.bpsgos.2023.01.005.Peer-Reviewed Original ResearchPosttraumatic stress disorderRight hippocampal volumeHippocampal volumeSymptom reductionPosttreatment magnetic resonance imagingPosttraumatic stress disorder treatment outcomeLarger hippocampal volumesDisorder treatment outcomesPTSD symptom reductionMagnetic resonance imagingGreater PTSD symptom reductionBetter prognosisClinical trialsTreatment outcomesDepressive symptomsTherapeutic outcomesPTSD treatmentResonance imagingTreatment studiesClinical targetsStress disorderPTSD symptomsSmall sample sizeHippocampal mechanismsTreatment
2017
Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders
Korem N, Lange R, Hillard C, Akirav I. Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders. Neuroscience 2017, 357: 285-294. PMID: 28624572, DOI: 10.1016/j.neuroscience.2017.06.015.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderWnt/β-catenin pathwayNucleus accumbensΒ-catenin pathwayΒ-catenin levelsΒ-cateninCannabinoid CB1/2 receptor agonistCB1/2 receptor agonistEndocannabinoid N-arachidonylethanolamineStress-related disordersΒ-catenin expressionReceptor agonistEndocannabinoid systemTherapeutic effectN-arachidonylethanolamineDepressive symptomsDevelopment of psychopathologyImpaired extinctionRatsStress disorderFear memoryTrauma memoriesRapid recoveryReminders modelAccumbens