2016
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing
Thomer L, Emolo C, Thammavongsa V, Kim H, McAdow M, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Journal Of Experimental Medicine 2016, 213: 293-301. PMID: 26880578, PMCID: PMC4813671, DOI: 10.1084/jem.20150074.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusBloodstream infectionsPhagocytic killingElicit cross-protective immune responsesCross-protective immune responsesProtective fibrin shieldS. aureus vaccineAureus vaccineClinical efficacyMRSA isolatesImmune cellsOpsonophagocytic killingFrequent causeImmune responseHost immunityHost prothrombinProtective antigenSpecific antibodiesInfectionSurface moleculesAntibodiesS. aureusStaphylococcus aureusAntibody therapeuticsStaphylococcal surface
2010
Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity. PLOS Pathogens 2010, 6: e1001036. PMID: 20700445, PMCID: PMC2916881, DOI: 10.1371/journal.ppat.1001036.Peer-Reviewed Original ResearchConceptsSpecific antibodiesFormation of abscessesHost immune cellsStaphylococcus aureus diseaseVon Willebrand factorProtective immunityAbscess formationStaphylococcal vaccineImmune cellsLethal bacteremiaNon-proteolytic activationAbscessCleavage of fibrinogenProtective antigenWillebrand factorS. aureusStaphylococcus aureusPseudocapsuleHistochemical stainingAntibodiesProthrombinHost tissuesCoagulaseVWbpAureus