2016
Serum mass profile signature as a biomarker of early lung cancer
Widlak P, Pietrowska M, Polanska J, Marczyk M, Ros-Mazurczyk M, Dziadziuszko R, Jassem J, Rzyman W. Serum mass profile signature as a biomarker of early lung cancer. Lung Cancer 2016, 99: 46-52. PMID: 27565913, DOI: 10.1016/j.lungcan.2016.06.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedArea Under CurveBiomarkers, TumorCase-Control StudiesEarly Detection of CancerFemaleHumansLung NeoplasmsMiddle AgedProteomicsROC CurveSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsEarly lung cancerLung cancerNegative predictive valuePredictive valueComputed tomographyEarly-stage lung cancerLow-dose computed tomographyIndeterminate pulmonary nodulesStage lung cancerPotential clinical usefulnessPositive predictive valueValidation cohortHealthy controlsClinical usefulnessDiscovery cohortBlood samplesIndependent cohortWeight serum fractionsPulmonary nodulesIndependent sample setCancerPatientsHealthy participantsMolecular biomarkersCohort
2015
Signal Partitioning Algorithm for Highly Efficient Gaussian Mixture Modeling in Mass Spectrometry
Polanski A, Marczyk M, Pietrowska M, Widlak P, Polanska J. Signal Partitioning Algorithm for Highly Efficient Gaussian Mixture Modeling in Mass Spectrometry. PLOS ONE 2015, 10: e0134256. PMID: 26230717, PMCID: PMC4521892, DOI: 10.1371/journal.pone.0134256.Peer-Reviewed Original ResearchConceptsGaussian mixture modelingMixture modelGaussian mixture modelPeak detectionProteomic mass spectraFeature extractionPartitioning algorithmEfficient algorithmSignal compressionSoftware packageAlgorithmMain ideaMixture modelingModeling approachModelingDatasetApplicationsDetectionPreliminary resultsDetection efficiencyProteomic datasetsMixture modeling approachModelDifferent typesHigh resolution
2014
Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
Jelonek K, Pietrowska M, Ros M, Zagdanski A, Suchwalko A, Polanska J, Marczyk M, Rutkowski T, Skladowski K, Clench MR, Widlak P. Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients. International Journal Of Molecular Sciences 2014, 15: 6609-6624. PMID: 24747595, PMCID: PMC4013650, DOI: 10.3390/ijms15046609.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCluster AnalysisHead and Neck NeoplasmsHumansLipidsLysophosphatidylcholinesMaleMiddle AgedPhosphatidylcholinesRadiotherapy DosageSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTime FactorsConceptsSerum lipidomeConformal radiotherapyMedium dosesEnd of radiotherapyNeck cancer patientsRadiation-induced changesWhole patient bodyBody responsePost-treatment samplesDoses of radiationBlood levelsCancer patientsNeck cancerBlood samplesRadiotherapyNormal tissuesPatientsDosesCancer radiotherapyLipidomePatient's bodyTreatment samplesTissueLipid extractsCancer
2011
Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: association with tumor progression.
Pietrowska M, Polańska J, Suwiński R, Wideł M, Rutkowski T, Marczyk M, Domińczyk I, Ponge L, Marczak L, Polański A, Widłak P. Comparison of peptide cancer signatures identified by mass spectrometry in serum of patients with head and neck, lung and colorectal cancers: association with tumor progression. International Journal Of Oncology 2011, 40: 148-56. PMID: 21894432, DOI: 10.3892/ijo.2011.1186.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCase-Control StudiesColorectal NeoplasmsDisease ProgressionHead and Neck NeoplasmsHumansLung NeoplasmsMaleNeoplasm ProteinsPeptide FragmentsProteomeSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsLung cancer samplesCancer samplesHealthy donorsSerum proteomeNon-small cell lung cancerNeck squamous cell cancerSquamous cell cancerCell lung cancerAdvanced cancer casesSera of patientsColorectal cancer samplesCancer signaturesInter-group analysisPeptide signaturesCell cancerClinical stageColorectal cancerCancer patientsLung cancerNeck cancerColorectal adenocarcinomaCancer casesSerum amyloidHealthy volunteersBlood samplesRadiation-related Changes in Serum Proteome Profiles Detected by Mass Spectrometry in Blood of Patients Treated with Radiotherapy Due to Larynx Cancer
WIDŁAK P, PIETROWSKA M, WOJTKIEWICZ K, RUTKOWSKI T, WYGODA A, MARCZAK Ł, MARCZYK M, POLAŃSKA J, WALASZCZYK A, DOMIŃCZYK I, SKŁADOWSKI K, STOBIECKI M, POLAŃSKI A. Radiation-related Changes in Serum Proteome Profiles Detected by Mass Spectrometry in Blood of Patients Treated with Radiotherapy Due to Larynx Cancer. Journal Of Radiation Research 2011, 52: 575-581. PMID: 21768750, DOI: 10.1269/jrr.11019.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkers, TumorBlood ProteinsCarcinoma, Squamous CellFemaleHumansLaryngeal NeoplasmsMaleMiddle AgedPilot ProjectsProteomeSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsMass spectrometrySerum samplesLarynx cancerTotal dosesSerum proteomeEnd of radiotherapyStart of radiotherapyRadiation-related changesBlood of patientsConsecutive blood samplesSerum proteome profilesMALDI-TOF mass spectrometryEarly time pointsHuman serum proteomeRadical radiotherapyPeptide ionsBlood samplesPatientsProteome profilesFinal irradiationRetrospective markerPilot studyRadiotherapyTime pointsAnalysed group