Importance of SNP Dependency Correction and Association Integration for Gene Set Analysis in Genome-Wide Association Studies
Marczyk M, Macioszek A, Tobiasz J, Polanska J, Zyla J. Importance of SNP Dependency Correction and Association Integration for Gene Set Analysis in Genome-Wide Association Studies. Frontiers In Genetics 2021, 12: 767358. PMID: 34956320, PMCID: PMC8696167, DOI: 10.3389/fgene.2021.767358.Peer-Reviewed Original ResearchGenome-wide association studiesOver-Representation AnalysisSingle nucleotide polymorphismsMeta-Analysis Gene-set EnrichmentSame geneTypical genome-wide association studyEnrichment analysisAssociation studiesGene-set analysisLD correctionGene set enrichmentGene expression dataGSEA-SNPCancer Genome Atlas (TCGA) databaseRelevant single nucleotide polymorphismsTranscriptomic levelGene levelExpression dataVariant associationsNonrandom associationGenesAssociation of SNPsMore lociAtlas databaseBreast cancer samples