2021
Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure
Stravitz RT, Fontana RJ, Meinzer C, Durkalski‐Mauldin V, Hanje AJ, Olson J, Koch D, Hamid B, Schilsky M, McGuire B, Ganger D, Liou I, Karvellas CJ, Rule JA, Lisman T, Clasen K, Reuben A, Cripps M, Lee WM, Group A. Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure. Hepatology 2021, 74: 937-949. PMID: 33636020, PMCID: PMC10668528, DOI: 10.1002/hep.31767.Peer-Reviewed Original ResearchConceptsALI/ALFROTEM parametersRotational thromboelastometryDisease severityAcute liver injury/failureAbnormal hemostatic profileSevere systemic complicationsAcute liver injuryBleeding eventsBleeding riskLiver transplantationSystemic complicationsHemostatic failureLiver injuryIllness severityNative liverAbnormal hemostasisHemostatic profileStudy groupHigh incidencePatientsNormal rangeLaboratory evidenceClot formationClot stability
2015
Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis
Karvellas CJ, Stravitz R, Battenhouse H, Lee WM, Schilsky ML, Group F. Therapeutic hypothermia in acute liver failure: A multicenter retrospective cohort analysis. Liver Transplantation 2015, 21: 4-12. PMID: 25308108, PMCID: PMC4939841, DOI: 10.1002/lt.24021.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAnalgesics, Non-NarcoticBrain EdemaChemical and Drug Induced Liver InjuryChi-Square DistributionFemaleHumansHypothermia, InducedLiver Failure, AcuteLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioRegistriesRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute liver failureNon-APAP patientsALF patientsTherapeutic hypothermiaAPAP patientsLiver failureUS Acute Liver Failure Study GroupAcute Liver Failure Study GroupImpact of THMulticenter retrospective cohort analysisTransplant-free survival rateEnd-stage liver diseaseAPAP-ALF patientsRetrospective cohort studyRetrospective cohort analysisAcetaminophen patientsSpontaneous survivalCerebral edemaCohort studyProspective trialHepatic encephalopathyLiver diseaseTracheal infectionGrade IIIWorse outcomes
2009
ICU Management of Acute Liver Failure
Schilsky ML, Honiden S, Arnott L, Emre S. ICU Management of Acute Liver Failure. Clinics In Chest Medicine 2009, 30: 71-87. PMID: 19186281, DOI: 10.1016/j.ccm.2008.10.001.Peer-Reviewed Original ResearchConceptsAcute liver failureLiver failureTeam approachGood ICU careOrganized team approachAcute liver injurySurvival of patientsBetter patient outcomesEarly disease recognitionLiver transplantationICU careLiver injuryICU managementPatient outcomesCritical carePatient managementSupportive measuresPatientsCareDisease recognitionICUTransplantationFailurePathophysiologyInjury
2008
Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests
Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Fontana RJ, Lee WM, Schilsky ML, Groups P. Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic tests. Hepatology 2008, 48: 1167-1174. PMID: 18798336, PMCID: PMC4881751, DOI: 10.1002/hep.22446.Peer-Reviewed Original ResearchConceptsAcute liver failureDiagnosis of ALFSerum copper levelsFulminant Wilson's diseaseWilson's diseaseLiver failureDiagnostic sensitivityEmergency liver transplantationChronic liver diseaseAlkaline phosphataseAvailable diagnostic testsCopper levelsAvailable laboratory testsALF patientsTransplant listingLikelihood ratioLiver transplantationSerum aminotransferasesLiver diseaseALT ratioSerum ceruloplasminBilirubin ratioPatientsSerum CpRapid diagnosis