2015
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
Barnea E, Almogi-Hazan O, Or R, Mueller M, Ria F, Weiss L, Paidas M. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult. Pharmacology & Therapeutics 2015, 156: 10-25. PMID: 26546485, DOI: 10.1016/j.pharmthera.2015.10.008.Peer-Reviewed Original ResearchConceptsPreImplantation FactorNeurological disordersAdverse maternal environmentSynthetic preimplantation factorEarly adverse eventsHigh safety profileFast track designationComplex neurological disorderEmbryonic-maternal interactionColon ulcerationPIF's effectHost diseaseLeukemia effectAdverse eventsLiver inflammationTransplant acceptanceBrain infectionNeuroprotective effectsAutoimmune disordersImmune suppressionNeuroprotective propertiesImmune modulationNeonatal prematuritySupraphysiological dosesSkin ulceration
2012
PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model)
Azar Y, Shainer R, Almogi-Hazan O, Bringer R, Compton SR, Paidas MJ, Barnea ER, Or R. PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model). Transplantation And Cellular Therapy 2012, 19: 519-528. PMID: 23266739, DOI: 10.1016/j.bbmt.2012.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCell ProliferationDendritic CellsGraft vs Host DiseaseGraft vs Leukemia EffectImmune ToleranceInflammationInterferon-gammaInterleukin-17LiverMiceMice, Inbred BALB CMice, Inbred C57BLNitric Oxide Synthase Type IIOxidative StressPeptidesSkinSpleenSurvival AnalysisT-Lymphocytes, RegulatoryTransplantation, HomologousConceptsBone marrow transplantationBeneficial GVL effectPreImplantation FactorAcute GVHDGVL effectHost diseaseImmune responseInducible nitric oxide synthase (iNOS) expressionAllogeneic bone marrow transplantationNitric oxide synthase expressionOxidative stressIL-17 levelsIFN-γ levelsSystemic immune responsesOxide synthase expressionAntigen-presenting cellsMurine BMT modelT cell proliferationNitric oxide secretionDonor-recipient matchingChemokine gene expressionLipopolysaccharide-activated macrophagesAcute graftAllogeneic embryosBeneficial graftPreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells
Barnea ER, Kirk D, Ramu S, Rivnay B, Roussev R, Paidas MJ. PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells. American Journal Of Obstetrics And Gynecology 2012, 207: 313.e1-313.e11. PMID: 23021695, DOI: 10.1016/j.ajog.2012.07.017.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsPreImplantation FactorSynthetic PIFBlood mononuclear cellsLymphocyte reactionMononuclear cellsImmune cellsSystemic effectsNaïve peripheral blood mononuclear cellsSynthetic preimplantation factorSystemic antiinflammatory effectMixed lymphocyte reactionImmune-modulatory propertiesTumor necrosis factorGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSPIF effectNonpregnant patientsDiabetes mellitusMale patientsAntiinflammatory effectsIL-4Immune modulationSubset populationsAntiinflammatory response
2004
Soluble monocyte cluster domain 163, a new global marker of anti‐inflammatory response, is elevated in the first trimester of pregnancy
Paidas M, Ku D, Davis B, Lockwood C, Arkel Y. Soluble monocyte cluster domain 163, a new global marker of anti‐inflammatory response, is elevated in the first trimester of pregnancy. Journal Of Thrombosis And Haemostasis 2004, 2: 1009-1010. PMID: 15140143, DOI: 10.1111/j.1538-7836.2004.00681.x.Peer-Reviewed Original Research