A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratoryPrior viral infection determines the mode and severity of monkeypox virus
Hussain H, Paidas M, Fadel A, Ramamoorthy R, Garcia E, Saadoon Z, Casmartino E, Mendez L, Williams E, Ruiz-Cordero R, Jayakumar A. Prior viral infection determines the mode and severity of monkeypox virus. International Journal Of Infectious Diseases 2023, 131: 95-99. PMID: 37001797, PMCID: PMC10060859, DOI: 10.1016/j.ijid.2023.03.047.Peer-Reviewed Original ResearchConceptsViral infectionHistory of HCVPrior viral infectionProdrome phaseSystemic complicationsCutaneous changesClinical presentationSkin findingsPathological characteristicsPrior infectionHistopathological analysisMonkeypox virusInfectionSkin architectureZoonotic virusesPatientsVirusSeveritySpecific microbesGenus OrthopoxvirusHCVComplicationsHIVHumansMPOX