Kidney Damage in Long COVID: Studies in Experimental Mice
Ramamoorthy R, Hussain H, Ravelo N, Sriramajayam K, Di Gregorio D, Paulrasu K, Chen P, Young K, Masciarella A, Jayakumar A, Paidas M. Kidney Damage in Long COVID: Studies in Experimental Mice. Biology 2023, 12: 1070. PMID: 37626956, PMCID: PMC10452084, DOI: 10.3390/biology12081070.Peer-Reviewed Original ResearchNeutrophil gelatinase-associated lipocalinSARS-CoV-2 infectionAcute infectionTubular necrosisLong COVIDTGF-β1Severe acute tubular necrosisInitial SARS-CoV-2 infectionAcute tubular necrosisGelatinase-associated lipocalinCoV-2 infectionProtein levelsInfiltration of macrophagesDevelopment of edemaMultiple organ systemsMMP-7 protein levelsCommon complicationKidney complicationsTLR-2IL-18Kidney damageKIM-1Renal fibrosisYKL-40NGAL mRNAMaternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates
Benny M, Bandstra E, Saad A, Lopez-Alberola R, Saigal G, Paidas M, Jayakumar A, Duara S. Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates. Pediatrics 2023, 151: e2022058271. PMID: 37021494, PMCID: PMC10467358, DOI: 10.1542/peds.2022-058271.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoV-2 infectionBrain injuryFetal brainSevere acute respiratory syndrome coronavirus disease 2Detectable SARS-CoV-2 antibodiesMaternal SARS-CoV-2 infectionSARS-CoV-2-positive mothersLong-term neurodevelopmental sequelaeMaternal SARS-CoV-2SARS-CoV-2 antibodiesStromal cell-derived factor-1Sudden unexpected infant deathInfant brainCell-derived factor-1Fetal vascular malperfusionSevere parenchymal atrophyHypoxic-ischemic encephalopathyBlood inflammatory markersUnexpected infant deathEarly-onset seizuresHuman chorionic gonadotropinOxidative stress injuryMonths of ageSARS-CoV-2 nucleocapsid protein