2023
Synthetic preimplantation factor plus hypothermia treatment reverses perinatal hypoxic-ischemic encephalopathy in rats
Paidas M, Ranganathan R, Melians M, Hussain H, Sriramajayam K, Muller M, Ahmad A, Dietrich D, Bramlett H, Barnea E, Jayakumar A. Synthetic preimplantation factor plus hypothermia treatment reverses perinatal hypoxic-ischemic encephalopathy in rats. American Journal Of Obstetrics And Gynecology 2023, 228: s365. DOI: 10.1016/j.ajog.2022.11.639.Peer-Reviewed Original Research
2019
PreImplantation Factor promotes Oligodentrocyte differentiation by modulating NCOR2 and long non-coding RNA H19 of the Oligodendrocyte Progenitor Cells
Spinelli M, Boucard C, Ornaghi S, Schoeberlein A, Keller I, Coman D, Hyder F, Zhang L, Haesler V, Bordey A, Barnea E, Paidas M, Surbek D, Mueller M. PreImplantation Factor promotes Oligodentrocyte differentiation by modulating NCOR2 and long non-coding RNA H19 of the Oligodendrocyte Progenitor Cells. Zeitschrift Für Geburtshilfe Und Neonatologie 2019, 223: e18-e18. DOI: 10.1055/s-0039-3401110.Peer-Reviewed Original Research
2015
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
Barnea E, Almogi-Hazan O, Or R, Mueller M, Ria F, Weiss L, Paidas M. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult. Pharmacology & Therapeutics 2015, 156: 10-25. PMID: 26546485, DOI: 10.1016/j.pharmthera.2015.10.008.Peer-Reviewed Original ResearchConceptsPreImplantation FactorNeurological disordersAdverse maternal environmentSynthetic preimplantation factorEarly adverse eventsHigh safety profileFast track designationComplex neurological disorderEmbryonic-maternal interactionColon ulcerationPIF's effectHost diseaseLeukemia effectAdverse eventsLiver inflammationTransplant acceptanceBrain infectionNeuroprotective effectsAutoimmune disordersImmune suppressionNeuroprotective propertiesImmune modulationNeonatal prematuritySupraphysiological dosesSkin ulceration
2013
Synthetic PreImplantation Factor (sPIF)# neuroprotective role in intracranial stem cell transplantation: Encephalopathy of prematurity rat model
Müller M, Paidas M, Schöberlein A, Messerli M, Barnea E, Surbek D. Synthetic PreImplantation Factor (sPIF)# neuroprotective role in intracranial stem cell transplantation: Encephalopathy of prematurity rat model. Zeitschrift Für Geburtshilfe Und Neonatologie 2013, 217 DOI: 10.1055/s-0033-1361330.Peer-Reviewed Original ResearchImmune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation
Shainer R, Azar Y, Almogi-Hazan O, Bringer R, Compton S, Paidas M, Barnea E, Or R. Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation. Conference Papers In Science 2013, 2013: 1-8. DOI: 10.1155/2013/718031.Peer-Reviewed Original ResearchBone marrow transplantationMarrow transplantationImmune responseAllogeneic bone marrow transplantationSyngeneic bone marrow transplantationAllogenic bone marrow transplantationImmune regulatory effectsProinflammatory gene expressionINOS gene expressionOxidative stress reductionImmune restorationPreImplantation FactorHost diseaseColon inflammationTransplant acceptanceINOS expressionSystemic immunityImmune regulationGene expressionMurine modelHematological diseasesWeight recoveryTransplantationOxidative stressTransplant success
2012
PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model)
Azar Y, Shainer R, Almogi-Hazan O, Bringer R, Compton SR, Paidas MJ, Barnea ER, Or R. PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model). Transplantation And Cellular Therapy 2012, 19: 519-528. PMID: 23266739, DOI: 10.1016/j.bbmt.2012.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCell ProliferationDendritic CellsGraft vs Host DiseaseGraft vs Leukemia EffectImmune ToleranceInflammationInterferon-gammaInterleukin-17LiverMiceMice, Inbred BALB CMice, Inbred C57BLNitric Oxide Synthase Type IIOxidative StressPeptidesSkinSpleenSurvival AnalysisT-Lymphocytes, RegulatoryTransplantation, HomologousConceptsBone marrow transplantationBeneficial GVL effectPreImplantation FactorAcute GVHDGVL effectHost diseaseImmune responseInducible nitric oxide synthase (iNOS) expressionAllogeneic bone marrow transplantationNitric oxide synthase expressionOxidative stressIL-17 levelsIFN-γ levelsSystemic immune responsesOxide synthase expressionAntigen-presenting cellsMurine BMT modelT cell proliferationNitric oxide secretionDonor-recipient matchingChemokine gene expressionLipopolysaccharide-activated macrophagesAcute graftAllogeneic embryosBeneficial graftPreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells
Barnea ER, Kirk D, Ramu S, Rivnay B, Roussev R, Paidas MJ. PreImplantation Factor (PIF) orchestrates systemic antiinflammatory response by immune cells: effect on peripheral blood mononuclear cells. American Journal Of Obstetrics And Gynecology 2012, 207: 313.e1-313.e11. PMID: 23021695, DOI: 10.1016/j.ajog.2012.07.017.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsPreImplantation FactorSynthetic PIFBlood mononuclear cellsLymphocyte reactionMononuclear cellsImmune cellsSystemic effectsNaïve peripheral blood mononuclear cellsSynthetic preimplantation factorSystemic antiinflammatory effectMixed lymphocyte reactionImmune-modulatory propertiesTumor necrosis factorGranulocyte-macrophage colony-stimulating factorColony-stimulating factorSPIF effectNonpregnant patientsDiabetes mellitusMale patientsAntiinflammatory effectsIL-4Immune modulationSubset populationsAntiinflammatory response57: Preimplantation factor (PIF*) orchestrates systemic anti-inflammatory response by immune cells: a direct effect on peripheral blood mononuclear cells (PBMC)
Barnea E, Paidas M, Kirk D, Ramu S, Rivnay B, Sathiyaseelan T, Stamatkin C, Roussev R. 57: Preimplantation factor (PIF*) orchestrates systemic anti-inflammatory response by immune cells: a direct effect on peripheral blood mononuclear cells (PBMC). American Journal Of Obstetrics And Gynecology 2012, 206: s36-s37. DOI: 10.1016/j.ajog.2011.10.083.Peer-Reviewed Original Research
2011
Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model
Weiss L, Or R, Jones RC, Amunugama R, JeBailey L, Ramu S, Bernstein SA, Yekhtin Z, Almogi-Hazan O, Shainer R, Reibstein I, Vortmeyer AO, Paidas MJ, Zeira M, Slavin S, Barnea ER. Preimplantation Factor (PIF*) reverses neuroinflammation while promoting neural repair in EAE model. Journal Of The Neurological Sciences 2011, 312: 146-157. PMID: 21996270, DOI: 10.1016/j.jns.2011.07.050.Peer-Reviewed Original ResearchConceptsInflammatory cellsPro-inflammatory cytokines/chemokinesPreserves islet functionCytokines/chemokinesSignificant neuroprotective effectsSpinal cord histologyPreImplantation FactorSplenocyte cytokinesEAE modelChronic modelNeuroprotective effectsMaternal immunityClinical indicesChronic paralysisSpinal cordJuvenile diabetesMulti-targeted actionSynaptic transmissionCord histologyIslet functionIL6 secretionCoagulation factorsNeural repairClinical testingDay 82Preimplantation factor (PIF*) directly targets and rescues embryos from adverse environment: relevance for recurrent pregnancy loss
Barnea E, Barder T, Stamatkin C, Coulam C, Roussev R, Absalon-Medina V, Gilbert R, Lubman D, Liu Y, Paidas M. Preimplantation factor (PIF*) directly targets and rescues embryos from adverse environment: relevance for recurrent pregnancy loss. Journal Of Reproductive Immunology 2011, 90: 141-142. DOI: 10.1016/j.jri.2011.06.023.Peer-Reviewed Original Research
2010
A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells
Paidas MJ, Krikun G, Huang SJ, Jones R, Romano M, Annunziato J, Barnea ER. A genomic and proteomic investigation of the impact of preimplantation factor on human decidual cells. American Journal Of Obstetrics And Gynecology 2010, 202: 459.e1-459.e8. PMID: 20452489, PMCID: PMC2867836, DOI: 10.1016/j.ajog.2010.03.024.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsDown syndrome cell adhesion moleculeSyndrome cell adhesion moleculeGlobal gene expressionProtein arraysQuantitative mass spectrometryPreImplantation FactorBinding protein 1B-cell lymphoma protein 2PIF interactionProteomic analysisProteomic investigationCell adhesion moleculeInsulin-degrading enzymeGene expressionPathway analysisApoptotic pathwayApoptotic processToll-like receptor 5Protein 2Amino acid peptideProtein 1Protein 15Synthetic preimplantation factorEndometrial stromal cells
2008
556: Preimplantation factor (PIF)* increases expression of key immunomodulatory factors suggesting a critical role in human implantation
Paidas M, Krikun G, Huang S, Romano M, Grinolds A, Barnea E. 556: Preimplantation factor (PIF)* increases expression of key immunomodulatory factors suggesting a critical role in human implantation. American Journal Of Obstetrics And Gynecology 2008, 199: s162. DOI: 10.1016/j.ajog.2008.09.586.Peer-Reviewed Original Research
2006
Preimplantation factor (PIF) upregulates first trimester toll like receptor-2, supporting the role of PIF as an embryo derived factor influencing maternal innate immunity
Paidas M, Krikun G, Buchwalder L, Schatz F, Godlewski K, Barnea E. Preimplantation factor (PIF) upregulates first trimester toll like receptor-2, supporting the role of PIF as an embryo derived factor influencing maternal innate immunity. American Journal Of Obstetrics And Gynecology 2006, 195: s140. DOI: 10.1016/j.ajog.2006.10.488.Peer-Reviewed Original Research