Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates
Benny M, Bandstra E, Saad A, Lopez-Alberola R, Saigal G, Paidas M, Jayakumar A, Duara S. Maternal SARS-CoV-2, Placental Changes and Brain Injury in 2 Neonates. Pediatrics 2023, 151: e2022058271. PMID: 37021494, PMCID: PMC10467358, DOI: 10.1542/peds.2022-058271.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoV-2 infectionBrain injuryFetal brainSevere acute respiratory syndrome coronavirus disease 2Detectable SARS-CoV-2 antibodiesMaternal SARS-CoV-2 infectionSARS-CoV-2-positive mothersLong-term neurodevelopmental sequelaeMaternal SARS-CoV-2SARS-CoV-2 antibodiesStromal cell-derived factor-1Sudden unexpected infant deathInfant brainCell-derived factor-1Fetal vascular malperfusionSevere parenchymal atrophyHypoxic-ischemic encephalopathyBlood inflammatory markersUnexpected infant deathEarly-onset seizuresHuman chorionic gonadotropinOxidative stress injuryMonths of ageSARS-CoV-2 nucleocapsid proteinSynthetic preimplantation factor plus hypothermia treatment reverses perinatal hypoxic-ischemic encephalopathy in rats
Paidas M, Ranganathan R, Melians M, Hussain H, Sriramajayam K, Muller M, Ahmad A, Dietrich D, Bramlett H, Barnea E, Jayakumar A. Synthetic preimplantation factor plus hypothermia treatment reverses perinatal hypoxic-ischemic encephalopathy in rats. American Journal Of Obstetrics And Gynecology 2023, 228: s365. DOI: 10.1016/j.ajog.2022.11.639.Peer-Reviewed Original Research