2023
Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis
Zorrilla-Vaca A, Grant M, Law M, Messinger C, Pelosi P, Varelmann D. Dexmedetomidine improves pulmonary outcomes in thoracic surgery under one-lung ventilation: A meta-analysis. Journal Of Clinical Anesthesia 2023, 93: 111345. PMID: 37988813, PMCID: PMC11034816, DOI: 10.1016/j.jclinane.2023.111345.Peer-Reviewed Original ResearchAcute respiratory distress syndromePostoperative pulmonary complicationsOne-lung ventilationThoracic surgeryDexmedetomidine groupPlacebo groupPostoperative atelectasisRandomized trialsOdds ratioIncidence of PPCsImpact of dexmedetomidineIntraoperative respiratory mechanicsPostoperative lung functionRespiratory distress syndromeML/cmHRandom-effects modelPostoperative pneumoniaPulmonary complicationsPulmonary outcomesIntrapulmonary shuntPostoperative FEV1Secondary outcomesDistress syndromeLung functionPrimary outcome
2022
Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis
Zorrilla-Vaca A, Grant M, Urman R, Frendl G. Individualised positive end-expiratory pressure in abdominal surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2022, 129: 815-825. PMID: 36031417, DOI: 10.1016/j.bja.2022.07.009.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureEnd-expiratory pressurePulmonary complicationsAbdominal surgerySystemic inflammationRisk ratioAcute respiratory distress syndromeLaird random-effects modelOverall pulmonary complicationsPostoperative pulmonary outcomesComposite primary outcomeEnd of surgerySystemic inflammatory markersRespiratory distress syndromeConfidence intervalsRandom-effects modelPostoperative atelectasisPrimary endpointPulmonary outcomesCochrane riskInflammatory markersLung injuryPostoperative hypoxaemiaSecondary outcomesBias tool