2002
Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.
Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development 2002, 129: 467-77. PMID: 11807038, DOI: 10.1242/dev.129.2.467.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCell DifferentiationCulture TechniquesDNA-Binding ProteinsFemaleGene TargetingHumansMaleMiceMice, KnockoutMicroscopy, FluorescenceNeuritesRetinaRetinal Ganglion CellsTranscription Factor Brn-3Transcription Factor Brn-3ATranscription Factor Brn-3BTranscription Factor Brn-3CTranscription FactorsConceptsDouble knockout miceGanglion cell differentiationRetinal ganglion cell differentiationRetinal ganglion cellsOptic chiasmKnockout miceGanglion cellsMost retinal ganglion cellsRetinal ganglion cell axonsRetinal ganglion cell developmentGanglion cell axonsAxon outgrowthGanglion cell developmentCell differentiationDorsal rootsProjection neuronsTrigeminal ganglionCell axonsRetinal explantsPOU domain transcription factorBrn3bBrn3cMiceChiasmInner ear
1999
The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons
Zhou C, Qiu Y, Pereira F, Crair M, Tsai S, Tsai M. The Nuclear Orphan Receptor COUP-TFI Is Required for Differentiation of Subplate Neurons and Guidance of Thalamocortical Axons. Neuron 1999, 24: 847-859. PMID: 10624948, DOI: 10.1016/s0896-6273(00)81032-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimetabolitesAxonsBromodeoxyuridineCarbocyaninesCell DeathCell DifferentiationCerebral CortexCOUP Transcription Factor IDNA-Binding ProteinsFluorescent DyesImmunohistochemistryIn Situ HybridizationMaleMiceMutationNeural PathwaysNeuronsReceptors, GlucocorticoidThalamusTranscription FactorsConceptsSubplate neuronsThalamocortical projectionsCortical layer IVLayer IV neuronsCell deathCorticothalamic connectivityAfferent innervationCerebral cortexThalamocortical axonsLayer IVNervous systemExcessive cell deathFactor INeuronal developmentNeuronsNuclear receptorsPremature cell deathInnervationImproper differentiationImportant regulatorOrphan memberDeathCritical roleDifferentiationFailure