2016
Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits
Xu HP, Burbridge TJ, Ye M, Chen M, Ge X, Zhou ZJ, Crair MC. Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits. Journal Of Neuroscience 2016, 36: 3871-3886. PMID: 27030771, PMCID: PMC4812142, DOI: 10.1523/jneurosci.3549-15.2016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAmacrine CellsAnimalsAnimals, NewbornCalciumCholera ToxinCholine O-AcetyltransferaseCholinergic AgentsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsIn Vitro TechniquesMiceMice, TransgenicPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsVesicular Glutamate Transport Protein 1Visual PathwaysConceptsEye-specific segregationVisual circuit developmentStarburst amacrine cellsStage III retinal wavesRetinal ganglion cellsRetinal wavesAmacrine cellsGlutamatergic wavesGanglion cellsSpontaneous activityVisual circuitsStage IICircuit developmentHigher-order visual areasNicotinic acetylcholine receptorsRetinal cell typesMammalian visual systemAcetylcholine receptorsΒ2-nAChRsVisual areasPatterned activityPatterning of activityΒ2 subunitCell typesCells
2011
Visual map development depends on the temporal pattern of binocular activity in mice
Zhang J, Ackman JB, Xu HP, Crair MC. Visual map development depends on the temporal pattern of binocular activity in mice. Nature Neuroscience 2011, 15: 298-307. PMID: 22179110, PMCID: PMC3267873, DOI: 10.1038/nn.3007.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornBrain MappingCalciumChannelrhodopsinsCritical Period, PsychologicalFunctional LateralityIn Vitro TechniquesLightLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicNeuronal PlasticityPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsSuperior ColliculiTime FactorsVision, BinocularVisual PathwaysConceptsDorsal lateral geniculate nucleusEye-specific segregationSpontaneous retinal wavesLateral geniculate nucleusPrimary visual cortexMouse visual systemBinocular activityRetinal wavesGeniculate nucleusCircuit refinementSuperior colliculusSpecific temporal featuresVisual cortexBursts of activityDefinitive evidenceVisual systemColliculusBinocularityCortexMiceActivity
2008
State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells
Kurotani T, Yamada K, Yoshimura Y, Crair MC, Komatsu Y. State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells. Neuron 2008, 57: 905-916. PMID: 18367091, PMCID: PMC2880402, DOI: 10.1016/j.neuron.2008.01.030.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAction PotentialsAnimalsAnimals, NewbornBicucullineDendritesDose-Response Relationship, DrugDose-Response Relationship, RadiationElectric StimulationExcitatory Amino Acid AntagonistsGABA AntagonistsGamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsNeural InhibitionPatch-Clamp TechniquesPyramidal CellsQuinoxalinesRatsRats, Sprague-DawleySpider VenomsVisual CortexConceptsL-type Ca2Slow-wave sleepSomatic inhibitionPyramidal neuronsLayer 5 pyramidal neuronsBidirectional modificationSlow membrane oscillationsRat visual cortexCortical pyramidal neuronsR-type Ca2Neocortical pyramidal cellsBehavioral statesNeuron responsivenessPyramidal cellsDepolarized phaseRepetitive firingVisual cortexReceptor exocytosisChannel activationInhibitionPotentiationNeuronsSleepMembrane oscillationsDepressionRetinocollicular Synapse Maturation and Plasticity Are Regulated by Correlated Retinal Waves
Shah RD, Crair MC. Retinocollicular Synapse Maturation and Plasticity Are Regulated by Correlated Retinal Waves. Journal Of Neuroscience 2008, 28: 292-303. PMID: 18171946, PMCID: PMC6671137, DOI: 10.1523/jneurosci.4276-07.2008.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornBehavior, AnimalDose-Response Relationship, RadiationElectric StimulationExcitatory Amino Acid AntagonistsIn Vitro TechniquesMiceMice, KnockoutNeuronal PlasticityN-MethylaspartatePatch-Clamp TechniquesQuinoxalinesReceptors, NicotinicRetinaSuperior ColliculiSynapsesSynaptic TransmissionVisual PathwaysConceptsFirst postnatal weekRetinal wavesPostnatal weekSynapse maturationAMPA/NMDA ratioRetinotopic map refinementSpontaneous retinal wavesNicotinic ACh receptorsSecond postnatal weekRetinocollicular synapsesSynapses decreasesPattern of activationNMDA ratioSynaptic strengtheningACh receptorsQuantal amplitudeRetinotopic map formationSuperior colliculusControl synapsesSynaptic changesCoincident activityPlasticity protocolsFirst weekBeta2 subunitWeeks
2006
Role of Efficient Neurotransmitter Release in Barrel Map Development
Lu HC, Butts DA, Kaeser PS, She WC, Janz R, Crair MC. Role of Efficient Neurotransmitter Release in Barrel Map Development. Journal Of Neuroscience 2006, 26: 2692-2703. PMID: 16525048, PMCID: PMC6675166, DOI: 10.1523/jneurosci.3956-05.2006.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornBlotting, WesternBrain MappingCalciumDizocilpine MaleateDose-Response Relationship, DrugDrug InteractionsElectric StimulationExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalGTP-Binding ProteinsIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMice, Mutant StrainsModels, NeurologicalNeural PathwaysNeuronal PlasticityNeurotransmitter AgentsN-MethylaspartatePatch-Clamp TechniquesSomatosensory CortexSynapsinsThalamusTime FactorsConceptsThalamocortical afferentsEfficient neurotransmitter releaseNeurotransmitter releaseBarrelless miceActivity-dependent processesNeuronal circuit formationAdenylyl cyclase IBarrel mapSynaptic transmissionPresynaptic terminalsPresynaptic functionCircuit formationCortical mapsMutant miceMiceNeuronal modulesRelease efficacyEfficient synaptic transmissionActive zone proteinsZone proteinEfficacyMap developmentRIM proteinsAC1 functionRelease
1997
Silent Synapses during Development of Thalamocortical Inputs
Isaac J, Crair M, Nicoll R, Malenka R. Silent Synapses during Development of Thalamocortical Inputs. Neuron 1997, 18: 269-280. PMID: 9052797, DOI: 10.1016/s0896-6273(00)80267-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesThalamocortical inputsSilent synapsesFunctional synapsesPostnatal day 8Rat somatosensory cortexActivity-dependent mechanismsActivity-dependent increaseEarly postnatal developmentSomatosensory cortexPostsynaptic activityTopographical projectionDay 8Postnatal developmentSynaptic connectionsSynaptic strengthSynapsesCortexSignificant proportionThalamusEarly developmentPotentiation