2007
Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice
Albright MJ, Weston MC, Inan M, Rosenmund C, Crair MC. Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice. Journal Of Neurophysiology 2007, 98: 1610-1625. PMID: 17581849, DOI: 10.1152/jn.00219.2007.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsField excitatory postsynaptic potentialsGAP-43Thalamocortical synapsesSynaptic responsesCompetitive glutamate receptor antagonistN-methyl-D-aspartate receptorsAcute brain slice preparationBarrel map formationThalamocortical synaptic responsesWild-type littermate controlsGlutamate receptor antagonistsBrain slice preparationGrowth-associated proteinThalamic innervationThalamic neuronsBarrel mapReceptor antagonistIsoxazolepropionate (AMPA) receptorsPostsynaptic potentialsLayer IVSlice preparationBarrel cortexSynaptic transmissionAMPAR function
2006
Role of Efficient Neurotransmitter Release in Barrel Map Development
Lu HC, Butts DA, Kaeser PS, She WC, Janz R, Crair MC. Role of Efficient Neurotransmitter Release in Barrel Map Development. Journal Of Neuroscience 2006, 26: 2692-2703. PMID: 16525048, PMCID: PMC6675166, DOI: 10.1523/jneurosci.3956-05.2006.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsAnimals, NewbornBlotting, WesternBrain MappingCalciumDizocilpine MaleateDose-Response Relationship, DrugDrug InteractionsElectric StimulationExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGene Expression Regulation, DevelopmentalGTP-Binding ProteinsIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMice, Mutant StrainsModels, NeurologicalNeural PathwaysNeuronal PlasticityNeurotransmitter AgentsN-MethylaspartatePatch-Clamp TechniquesSomatosensory CortexSynapsinsThalamusTime FactorsConceptsThalamocortical afferentsEfficient neurotransmitter releaseNeurotransmitter releaseBarrelless miceActivity-dependent processesNeuronal circuit formationAdenylyl cyclase IBarrel mapSynaptic transmissionPresynaptic terminalsPresynaptic functionCircuit formationCortical mapsMutant miceMiceNeuronal modulesRelease efficacyEfficient synaptic transmissionActive zone proteinsZone proteinEfficacyMap developmentRIM proteinsAC1 functionRelease