2007
Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice
Albright MJ, Weston MC, Inan M, Rosenmund C, Crair MC. Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice. Journal Of Neurophysiology 2007, 98: 1610-1625. PMID: 17581849, DOI: 10.1152/jn.00219.2007.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsField excitatory postsynaptic potentialsGAP-43Thalamocortical synapsesSynaptic responsesCompetitive glutamate receptor antagonistN-methyl-D-aspartate receptorsAcute brain slice preparationBarrel map formationThalamocortical synaptic responsesWild-type littermate controlsGlutamate receptor antagonistsBrain slice preparationGrowth-associated proteinThalamic innervationThalamic neuronsBarrel mapReceptor antagonistIsoxazolepropionate (AMPA) receptorsPostsynaptic potentialsLayer IVSlice preparationBarrel cortexSynaptic transmissionAMPAR function
2005
Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components
Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ. Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components. Neuron 2005, 46: 219-232. PMID: 15848801, DOI: 10.1016/j.neuron.2005.02.029.Peer-Reviewed Original ResearchConceptsExocyst componentsComplex of proteinsCell polaritySec15Specific cell adhesionSpecific proteinsMutant neuronsSubcellular distributionCell adhesionCell lethalityExocystNeuronal targetingSec5Neurite outgrowthSynaptic specificityCell viabilityProteinSeparable functionsSec6Sec8SubcomplexMislocalizationYeastGenesComponents persist