2013
Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission
Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N, Crair MC. Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission. Neuron 2013, 79: 970-986. PMID: 24012009, PMCID: PMC3768017, DOI: 10.1016/j.neuron.2013.06.043.Peer-Reviewed Original ResearchConceptsThalamocortical neurotransmissionCortical developmentNeuronal differentiationGlutamatergic synaptic transmissionSuperficial cortical laminaeEarly cortical developmentActivity-dependent factorsThalamocortical neuronsSomatosensory cortexCortical cytoarchitectureCortical laminationSynaptic transmissionNeuronal activityCortical laminaeCytoarchitectonic criteriaExtrinsic activityNeurotransmissionCortical columnsMolecular cuesNeuronsMorphologic developmentLittle evidenceColumnar developmentGene expressionExtrinsic factors
2011
How do barrels form in somatosensory cortex?
Li H, Crair MC. How do barrels form in somatosensory cortex? Annals Of The New York Academy Of Sciences 2011, 1225: 119-129. PMID: 21534999, PMCID: PMC4700879, DOI: 10.1111/j.1749-6632.2011.06024.x.Peer-Reviewed Original Research
2008
Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development
Iwasato T, Inan M, Kanki H, Erzurumlu RS, Itohara S, Crair MC. Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development. Journal Of Neuroscience 2008, 28: 5931-5943. PMID: 18524897, PMCID: PMC2733830, DOI: 10.1523/jneurosci.0815-08.2008.Peer-Reviewed Original ResearchConceptsTC synapsesLayer IV barrel neuronsCritical period plasticityPrimary somatosensory cortexFormation of barrelsAdenylyl cyclase 1Knock-out (KO) miceType 1 adenylyl cyclaseDendritic asymmetryBarrel neuronsThalamocortical synapsesActivity-dependent mannerTrigeminal pathwayFormation of cAMPSomatosensory cortexBarrel cortexBarrel developmentSynapse maturationPresynaptic maturationBarrel hollowsTC axonsSubcortical regionsFunctional maturationMutant miceBRL mice
2007
Development of Cortical Maps: Perspectives From the Barrel Cortex
Inan M, Crair MC. Development of Cortical Maps: Perspectives From the Barrel Cortex. The Neuroscientist 2007, 13: 49-61. PMID: 17229975, DOI: 10.1177/1073858406296257.Peer-Reviewed Original ResearchConceptsBarrel mapThalamic axonsBarrel cortexBarrel map formationActivity-dependent cuesMolecular cuesSensory afferentsMotor cortexPrimary somatosensoryThalamocortical axonsSomatosensory cortexCortical neuronsSynapse maturationNeuronal activityFunctional maturationVentricular cellsCortical mapsCortexAxonsNeocortical developmentWiring principlesCortical patterningMammalian neocortexNeocortexNeurons
1999
Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording
Higashi S, Crair MC, Kurotani T, Inokawa H, Toyama K. Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording. Neuroscience 1999, 91: 439-452. PMID: 10366001, DOI: 10.1016/s0306-4522(98)00666-6.Peer-Reviewed Original ResearchConceptsInfraorbital nerve cutNerve cutNormal ratsLayer IVSomatosensory cortexDextran amine labelingThalamocortical slice preparationPostnatal day 7Cytochrome oxidase stainingThalamocortical transmissionThalamocortical connectionsDextran amineThalamocortical axonsThalamic stimulationBarrel cortexFunctional synapsesSlice preparationAxon terminalsVoltage-sensitive dyeTerminal arborsAltered spatial patternDay 7P5-P6RatsBarrel formation
1997
Silent Synapses during Development of Thalamocortical Inputs
Isaac J, Crair M, Nicoll R, Malenka R. Silent Synapses during Development of Thalamocortical Inputs. Neuron 1997, 18: 269-280. PMID: 9052797, DOI: 10.1016/s0896-6273(00)80267-6.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesThalamocortical inputsSilent synapsesFunctional synapsesPostnatal day 8Rat somatosensory cortexActivity-dependent mechanismsActivity-dependent increaseEarly postnatal developmentSomatosensory cortexPostsynaptic activityTopographical projectionDay 8Postnatal developmentSynaptic connectionsSynaptic strengthSynapsesCortexSignificant proportionThalamusEarly developmentPotentiation
1995
A critical period for long-term potentiation at thalamocortical synapses
Crair M, Malenka R. A critical period for long-term potentiation at thalamocortical synapses. Nature 1995, 375: 325-328. PMID: 7753197, DOI: 10.1038/375325a0.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesNMDA receptor-mediated synaptic currentsN-methyl-D-aspartate receptor-dependent long-term potentiationReceptor-mediated synaptic currentsCritical periodRat somatosensory cortexActivity-dependent processesSomatosensory cortexThalamic axonsCortical circuitryNormal connectivitySynaptic currentsTopographical projectionSynaptic connectionsWhisker barrelsLoss of susceptibilitySensory perturbationsLTPPotentiationCortexSynapsesNormal developmentCompelling evidenceLikely mechanism