2019
Visual Cortex Gains Independence from Peripheral Drive before Eye Opening
Gribizis A, Ge X, Daigle TL, Ackman JB, Zeng H, Lee D, Crair MC. Visual Cortex Gains Independence from Peripheral Drive before Eye Opening. Neuron 2019, 104: 711-723.e3. PMID: 31561919, PMCID: PMC6872942, DOI: 10.1016/j.neuron.2019.08.015.Peer-Reviewed Original ResearchConceptsSuperior colliculusEarly functional developmentSpontaneous neuronal activitySecond postnatal weekPrimary visual cortexPeripheral driveCortex maturesRetinal activityPostnatal weekNeuronal activityDirect projectionsVisual cortexMammalian brainSensory peripheryVisual-spatial perceptionEye openingFunctional developmentPeripheral activityColliculusWeeksDistinct pathwaysPathwayRelative functionV1Thalamus
2012
Role of adenylate cyclase 1 in retinofugal map development
Dhande OS, Bhatt S, Anishchenko A, Elstrott J, Iwasato T, Swindell EC, Xu H, Jamrich M, Itohara S, Feller MB, Crair MC. Role of adenylate cyclase 1 in retinofugal map development. The Journal Of Comparative Neurology 2012, 520: 1562-1583. PMID: 22102330, PMCID: PMC3563095, DOI: 10.1002/cne.23000.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusDorsal lateral geniculate nucleusAdenylate cyclase 1Superior colliculusRetinal wavesRetinal ganglion cell projectionsEye-specific segregationGanglion cell projectionsSpontaneous retinal wavesSecond postnatal weekActivity-dependent processesCyclase 1Production of cAMPRGC axonsGeniculate nucleusPostnatal weekMammalian visual systemDevelopment of retinotopySomatotopic mapMutant miceSensory peripheryMiceConditional deletionTermination zonesDependent manner
2004
Adenylate Cyclase 1 dependent refinement of retinotopic maps in the mouse
Plas DT, Visel A, Gonzalez E, She WC, Crair MC. Adenylate Cyclase 1 dependent refinement of retinotopic maps in the mouse. Vision Research 2004, 44: 3357-3364. PMID: 15536003, DOI: 10.1016/j.visres.2004.09.036.Peer-Reviewed Original ResearchConceptsAdenylate cyclase 1Retino-collicular pathwayTopographic map refinementActivity-dependent factorsSuperior colliculusRetinotopic mapMutant miceSensory peripheryCellular mechanismsCyclase 1Superficial layersColliculusNeuronal mapsMiceGross topographyLittle evidenceDependent factorsMap refinementBiochemical techniques