2015
Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency
Xu HP, Burbridge TJ, Chen MG, Ge X, Zhang Y, Zhou ZJ, Crair MC. Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency. Developmental Neurobiology 2015, 75: 621-640. PMID: 25787992, PMCID: PMC4697738, DOI: 10.1002/dneu.22288.Peer-Reviewed Original ResearchConceptsSpontaneous retinal activityEye-specific segregationRetinal activityRetinal ganglion cell projectionsEye-specific projectionsGanglion cell projectionsPrecise neural connectionsRetinotopic map refinementSpontaneous retinal wavesNicotinic acetylcholine receptorsInstructive roleEye of originRetinal wavesRetinotopic refinementSpontaneous activityRetinotopic mapAcetylcholine receptorsDevelopment of retinotopyBrain wiringPermissive roleMutant miceNeural connectionsOverall activity levelsSpontaneous wavesMice
2012
Role of adenylate cyclase 1 in retinofugal map development
Dhande OS, Bhatt S, Anishchenko A, Elstrott J, Iwasato T, Swindell EC, Xu H, Jamrich M, Itohara S, Feller MB, Crair MC. Role of adenylate cyclase 1 in retinofugal map development. The Journal Of Comparative Neurology 2012, 520: 1562-1583. PMID: 22102330, PMCID: PMC3563095, DOI: 10.1002/cne.23000.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusDorsal lateral geniculate nucleusAdenylate cyclase 1Superior colliculusRetinal wavesRetinal ganglion cell projectionsEye-specific segregationGanglion cell projectionsSpontaneous retinal wavesSecond postnatal weekActivity-dependent processesCyclase 1Production of cAMPRGC axonsGeniculate nucleusPostnatal weekMammalian visual systemDevelopment of retinotopySomatotopic mapMutant miceSensory peripheryMiceConditional deletionTermination zonesDependent manner
2011
An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development
Xu HP, Furman M, Mineur YS, Chen H, King SL, Zenisek D, Zhou ZJ, Butts DA, Tian N, Picciotto MR, Crair MC. An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development. Neuron 2011, 70: 1115-1127. PMID: 21689598, PMCID: PMC3119851, DOI: 10.1016/j.neuron.2011.04.028.Peer-Reviewed Original ResearchConceptsSpontaneous retinal activityRetinal activityRetinal ganglion cell projectionsEye-specific segregationGanglion cell projectionsSpontaneous retinal wavesActivity-dependent refinementRetinal ganglion cellsMouse visual systemComplex neural circuitsEye of originRetinal wavesGanglion cellsRetinotopic refinementNeuronal activitySpontaneous activityMammalian visual systemAcetylcholine receptorsNeuronal connectivityMammalian brainNeural circuitsOverall activity levelsActivity levelsBrainVisual system