2019
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagates
2008
State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells
Kurotani T, Yamada K, Yoshimura Y, Crair MC, Komatsu Y. State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells. Neuron 2008, 57: 905-916. PMID: 18367091, PMCID: PMC2880402, DOI: 10.1016/j.neuron.2008.01.030.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAction PotentialsAnimalsAnimals, NewbornBicucullineDendritesDose-Response Relationship, DrugDose-Response Relationship, RadiationElectric StimulationExcitatory Amino Acid AntagonistsGABA AntagonistsGamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsNeural InhibitionPatch-Clamp TechniquesPyramidal CellsQuinoxalinesRatsRats, Sprague-DawleySpider VenomsVisual CortexConceptsL-type Ca2Slow-wave sleepSomatic inhibitionPyramidal neuronsLayer 5 pyramidal neuronsBidirectional modificationSlow membrane oscillationsRat visual cortexCortical pyramidal neuronsR-type Ca2Neocortical pyramidal cellsBehavioral statesNeuron responsivenessPyramidal cellsDepolarized phaseRepetitive firingVisual cortexReceptor exocytosisChannel activationInhibitionPotentiationNeuronsSleepMembrane oscillationsDepression